DBU催化N,N ' -羰基二咪唑介导的酰胺化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2009-12-16 DOI:10.1021/ol9026599

Claude Larrivée-Aboussafy, Brian P. Jones, Kristin E. Price, Mark A. Hardink, Robert W. McLaughlin, Brett M. Lillie, Joel M. Hawkins, Rajappa Vaidyanathan*

引用次数: 63

摘要

1,8-二氮杂环[5.4.0]十一-7-烯(DBU)催化酰基咪唑的酰胺化反应。对于传统上不反应的缺电子苯胺，速率加速尤为明显。DBU很容易获得，与1-羟基苯并三唑等更常用的催化剂相比，它具有安全性和成本优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

DBU Catalysis of N,N′-Carbonyldiimidazole-Mediated Amidations§

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DBU Catalysis of N,N′-Carbonyldiimidazole-Mediated Amidations§

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) has been found to catalyze the amidation of acyl imidazoles. The rate acceleration is especially evident with traditionally unreactive, electron-deficient anilines. DBU is readily available and offers safety and cost advantages over more commonly employed catalysts such as 1-hydroxybenzotriazole.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.