Maria Rudkjær Mikkelsen, Sigrid Bruun Nielsen, Edna Stage, Elisabeth R Mathiesen, Peter Damm
{"title":"母亲HbA1c高与新生儿超重有关。","authors":"Maria Rudkjær Mikkelsen, Sigrid Bruun Nielsen, Edna Stage, Elisabeth R Mathiesen, Peter Damm","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The aims of this study were to determine the prevalence of women with gestational diabetes mellitus (GDM) not obtaining HbA1c within the normal range (≤ 5.6%) before delivery and to examine whether elevated HbA1c values are associated with an increased risk of large for gestational age (LGA) infants.</p><p><strong>Material and methods: </strong>A population of 148 women with singleton pregnancies who had been diagnosed with GDM < 34 weeks, and who had a minimum of two HbA1c tests with a ≥ 3 week interval. They were divided into those obtaining a HbA1c ≤ 5.6%, and those who did not before delivery and further stratified according to baseline HbA1c ≤ or > 5.6%. The primary outcome was LGA infants.</p><p><strong>Results: </strong>A total of 51 (34%) women did not obtain a HbA1c ≤ 5.6% before delivery. The median HbA1c before delivery was 5.9% versus 5.3% in the two groups. At baseline, body mass index and HbA1c were higher in the women not obtaining the goal (30.9 versus 27.8 kg/m², 5.9% versus 5.1%, both p < 0.01). Women with an elevated HbA1c before delivery had a higher prevalence of LGA infants (adjusted odds ratio (OR) 3.1 (95% confidence interval (CI) 1.3-7.6) and neonatal hypoglycaemia (adjusted OR 6.2 (95% CI 1.3-29.0). Other pregnancy outcomes were similar in the two groups. Stratification according to baseline HbA1c did not seem to change the result.</p><p><strong>Conclusion: </strong>Women with GDM not obtaining HbA1c within the normal range before delivery had a threefold increased risk of having an LGA infant and a sixfold increased risk of neonatal hypoglycaemia.</p><p><strong>Funding: </strong>not relevant.</p><p><strong>Trial registration: </strong>not relevant.</p>","PeriodicalId":11019,"journal":{"name":"Danish medical bulletin","volume":"58 9","pages":"A4309"},"PeriodicalIF":0.0000,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High maternal HbA1c is associated with overweight in neonates.\",\"authors\":\"Maria Rudkjær Mikkelsen, Sigrid Bruun Nielsen, Edna Stage, Elisabeth R Mathiesen, Peter Damm\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aims of this study were to determine the prevalence of women with gestational diabetes mellitus (GDM) not obtaining HbA1c within the normal range (≤ 5.6%) before delivery and to examine whether elevated HbA1c values are associated with an increased risk of large for gestational age (LGA) infants.</p><p><strong>Material and methods: </strong>A population of 148 women with singleton pregnancies who had been diagnosed with GDM < 34 weeks, and who had a minimum of two HbA1c tests with a ≥ 3 week interval. They were divided into those obtaining a HbA1c ≤ 5.6%, and those who did not before delivery and further stratified according to baseline HbA1c ≤ or > 5.6%. The primary outcome was LGA infants.</p><p><strong>Results: </strong>A total of 51 (34%) women did not obtain a HbA1c ≤ 5.6% before delivery. The median HbA1c before delivery was 5.9% versus 5.3% in the two groups. At baseline, body mass index and HbA1c were higher in the women not obtaining the goal (30.9 versus 27.8 kg/m², 5.9% versus 5.1%, both p < 0.01). Women with an elevated HbA1c before delivery had a higher prevalence of LGA infants (adjusted odds ratio (OR) 3.1 (95% confidence interval (CI) 1.3-7.6) and neonatal hypoglycaemia (adjusted OR 6.2 (95% CI 1.3-29.0). Other pregnancy outcomes were similar in the two groups. Stratification according to baseline HbA1c did not seem to change the result.</p><p><strong>Conclusion: </strong>Women with GDM not obtaining HbA1c within the normal range before delivery had a threefold increased risk of having an LGA infant and a sixfold increased risk of neonatal hypoglycaemia.</p><p><strong>Funding: </strong>not relevant.</p><p><strong>Trial registration: </strong>not relevant.</p>\",\"PeriodicalId\":11019,\"journal\":{\"name\":\"Danish medical bulletin\",\"volume\":\"58 9\",\"pages\":\"A4309\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Danish medical bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Danish medical bulletin","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本研究的目的是确定妊娠期糖尿病(GDM)妇女在分娩前HbA1c未达到正常范围(≤5.6%)的患病率，并检查HbA1c升高是否与大胎龄儿(LGA)的风险增加有关。材料和方法:148名被诊断为GDM < 34周的单胎妊娠妇女，至少有两次HbA1c检测，间隔≥3周。将患者分为HbA1c≤5.6%组和分娩前HbA1c≤5.6%组，根据基线HbA1c≤或> 5.6%进一步分层。主要结局为LGA婴儿。结果:共有51名(34%)女性在分娩前HbA1c未达到≤5.6%。分娩前HbA1c中位数为5.9%，而两组为5.3%。基线时，未达到目标的女性体重指数和糖化血红蛋白更高(30.9 vs 27.8 kg/m²，5.9% vs 5.1%， p < 0.01)。分娩前HbA1c升高的妇女有更高的LGA婴儿患病率(校正优势比(OR) 3.1(95%置信区间(CI) 1.3-7.6)和新生儿低血糖(校正优势比(OR) 6.2 (95% CI 1.3-29.0)。两组的其他妊娠结局相似。根据基线HbA1c分层似乎没有改变结果。结论:分娩前HbA1c未在正常范围内的GDM妇女生下LGA婴儿的风险增加了3倍，新生儿低血糖的风险增加了6倍。资金:不相关。试验注册:不相关。
High maternal HbA1c is associated with overweight in neonates.
Introduction: The aims of this study were to determine the prevalence of women with gestational diabetes mellitus (GDM) not obtaining HbA1c within the normal range (≤ 5.6%) before delivery and to examine whether elevated HbA1c values are associated with an increased risk of large for gestational age (LGA) infants.
Material and methods: A population of 148 women with singleton pregnancies who had been diagnosed with GDM < 34 weeks, and who had a minimum of two HbA1c tests with a ≥ 3 week interval. They were divided into those obtaining a HbA1c ≤ 5.6%, and those who did not before delivery and further stratified according to baseline HbA1c ≤ or > 5.6%. The primary outcome was LGA infants.
Results: A total of 51 (34%) women did not obtain a HbA1c ≤ 5.6% before delivery. The median HbA1c before delivery was 5.9% versus 5.3% in the two groups. At baseline, body mass index and HbA1c were higher in the women not obtaining the goal (30.9 versus 27.8 kg/m², 5.9% versus 5.1%, both p < 0.01). Women with an elevated HbA1c before delivery had a higher prevalence of LGA infants (adjusted odds ratio (OR) 3.1 (95% confidence interval (CI) 1.3-7.6) and neonatal hypoglycaemia (adjusted OR 6.2 (95% CI 1.3-29.0). Other pregnancy outcomes were similar in the two groups. Stratification according to baseline HbA1c did not seem to change the result.
Conclusion: Women with GDM not obtaining HbA1c within the normal range before delivery had a threefold increased risk of having an LGA infant and a sixfold increased risk of neonatal hypoglycaemia.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
