{"title":"临床试验设计基础。","authors":"Scott R Evans","doi":"10.6030/1939-067x-3.1.19","DOIUrl":null,"url":null,"abstract":"<p><p>Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.</p>","PeriodicalId":88544,"journal":{"name":"Journal of experimental stroke & translational medicine","volume":"3 1","pages":"19-27"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083073/pdf/nihms275041.pdf","citationCount":"54","resultStr":"{\"title\":\"Fundamentals of clinical trial design.\",\"authors\":\"Scott R Evans\",\"doi\":\"10.6030/1939-067x-3.1.19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.</p>\",\"PeriodicalId\":88544,\"journal\":{\"name\":\"Journal of experimental stroke & translational medicine\",\"volume\":\"3 1\",\"pages\":\"19-27\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083073/pdf/nihms275041.pdf\",\"citationCount\":\"54\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of experimental stroke & translational medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6030/1939-067x-3.1.19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of experimental stroke & translational medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6030/1939-067x-3.1.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.
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