在未经治疗的人群中收缩压降低和死亡率下降:来自哥本哈根市心脏研究的结果

Ulla O Andersen, Jacob L Marott, Gorm B Jensen
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引用次数: 8

摘要

目的:本研究的目的是评估可能与人群收缩压(SBP)发展相关的30年死亡风险的发展,并评估未治疗人群中与bp相关的死亡风险的可能长期趋势。设计:哥本哈根城市心脏研究是一项前瞻性纵向流行病学研究。本分析包括调查1(1976-78)和调查3(1991-94)的参与者。方法:血压测量等方法完全标准化,在整个观察期内保持不变。问卷由参与者填写,并由技术人员在采访参与者时进行复核。结果:18 077人参与。年龄、收缩压、舒张压、胆固醇、BMI、糖尿病、性别和习惯性体育活动是所有年龄组全因死亡的显著预测因子。调查3的危险因素调整后的全因死亡风险明显低于调查1。在老年人中,死亡风险没有增加。在40-49岁和50-59岁年龄组中,调查差异表明,与调查1中同龄的人相比,预期寿命有明显延长的趋势。血压与死亡率之间的关系保持不变。结论:在年轻和中年人群中观察到全因死亡的风险下降。同一年龄组收缩压的降低和死亡风险的降低表明收缩压在不同年龄组预期寿命改善中的作用。收缩压对死亡率的影响在随访期间没有改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decreasing systolic blood pressure and declining mortality rates in an untreated population: results from the Copenhagen City Heart Study.

Objective: The aim of the present study was to evaluate developments in 30 years mortality risk that may be associated with developments in population systolic blood pressure (SBP) and to evaluate possible secular trends in BP-associated mortality risk in the untreated population.

Design: The Copenhagen City Heart Study is a prospective longitudinal epidemiological study. The present analysis comprised participants from survey 1 (1976-78) and 3 (1991-94).

Methods: BP measurements and other methods were fully standardized and unchanged throughout the observation period. Questionnaires were completed by the participants and double checked by the technicians while they were interviewing the participants.

Results: 18 077 persons participated. Age, systolic BP, diastolic BP, cholesterol, BMI, diabetes, gender and habitual physical activity were significant predictors of all-cause death in all age groups. Risk factor adjusted risk for all-cause death was significantly lower in survey 3 compared with survey 1. Among elderly people, there was no development in mortality risk. In the age groups 40-49 years and 50-59 years there were survey differences indicating a significant trend towards longer life expectancy compared with their age-matched counterparts in survey 1. The association between BP and mortality remained unchanged.

Conclusion: A declining risk of all-cause death was observed in the younger and middle-aged cohorts of the population. The decrease in systolic BP and decline in mortality risk in the same age groups points to a role of systolic BP in age-cohort differentiated improvements of life expectancy. The effect of systolic BP on mortality did not change during follow-up.

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