体外神经元生长的建模:模拟工具NETMORPH和CX3D的比较。

J Aćimović, T Mäki-Marttunen, R Havela, H Teppola, M-L Linne
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引用次数: 19

摘要

我们使用最近发布的两个工具NETMORPH和CX3D来模拟神经元网络的生长。这项工作的目标是:(1)检查和比较模拟工具,(2)构建新皮层培养物的生长模型,(3)使用标准图论方法表征生长过程中网络连通性的变化。新皮层培养的参数是在参考了文献中的实验和计算工作后选择的。培养的前三周是树突和轴突树突广泛发育的时期,也是神经元之间突触连接建立的时期。我们模拟了网络从第一天到第21天的增长。结果表明,在选择适当的参数时,仿真器可以再现实验得到的连通性。所选择的图论方法可以捕捉到生长过程中的结构变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D.

Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D.

Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D.

Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D.

We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.

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