聚乙二醇化干扰素和利巴韦林治疗基因型1型高病毒滴度慢性丙型肝炎的差异影响

Hepatitis research and treatment Pub Date : 2010-01-01 Epub Date: 2010-08-23 DOI:10.1155/2010/702748
Makoto Numata, Tatehiro Kagawa, Sei-Ichiro Kojima, Shunji Hirose, Naruhiko Nagata, Koichi Shiraishi, Norihito Watanabe, Hirokazu Shiozawa, Yasuhiro Nishizaki, Shigeyuki Motegi, Shinji Takashimizu, Jun-Ichiro Kamochi, Mitsuru Wasada, Takashi Ohno, Yoshihiro Tei, Atsushi Nakano, Takuji Yamada, Kazuhiro Atsukawa, Tetsu Watanabe, Tetsuya Mine
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引用次数: 5

摘要

为了明确依从性的影响,我们在9家转诊医院用聚乙二醇化干扰素(peg-IFN)和利巴韦林治疗122名基因型1型高病毒滴度慢性丙型肝炎患者48周,并评估预后因素,重点关注治疗依从性。本研究包括68例(55.7%)treatment-naïve患者和54例(44.3%)对既往治疗无反应的患者。多变量分析显示,坚持使用peg-IFN和利巴韦林是唯一显著的预测因素。持续病毒学应答(SVR)率分别为72.2%、19.0%和27.3%
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Differential impact of adherence to pegylated interferon and ribavirin in the treatment of genotype 1 high viral titer chronic hepatitis C.

Differential impact of adherence to pegylated interferon and ribavirin in the treatment of genotype 1 high viral titer chronic hepatitis C.

Differential impact of adherence to pegylated interferon and ribavirin in the treatment of genotype 1 high viral titer chronic hepatitis C.

Differential impact of adherence to pegylated interferon and ribavirin in the treatment of genotype 1 high viral titer chronic hepatitis C.

To clarify the impact of adherence, we treated 122 genotype 1 high viral titer chronic hepatitis C patients with pegylated interferon (peg-IFN) and ribavirin for 48 weeks at nine referral hospitals, and evaluated the prognostic factors with a focus on the adherence to the treatment. This study included 68 (55.7%) treatment-naïve patients and 54 (44.3%) patients who did not respond to the previous treatment. Multivariate analysis revealed adherence to peg-IFN and ribavirin as the only significant predictor. Sustained virological response (SVR) rate was 72.2%, 19.0%, and 27.3% in patients given ≥80%, 60%-80%, and <60% dose peg-IFN, respectively, and was 68.6%, 41.2%, and 5.3% in those given ≥80%, 60%-80%, and <60% dose ribavirin, respectively. SVR rate sharply fell when exposure to peg-IFN was below 80% whereas it decreased in a stepwise manner as for ribavirin. Therefore, ≥80% of peg-IFN and as much as possible dose of ribavirin are desired to achieve SVR in the treatment of genotype 1 high viral titer chronic hepatitis C.

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