Paula M Frew, Mark J Mulligan, Su-I Hou, Kayshin Chan, Carlos del Rio
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METHODS: Descriptive statistics, t tests, and chi-square tests were conducted to ascertain differences between the groups, and ordinal logistic regressions examined the influences of the above-mentioned factors on a critical outcome, future HIV vaccine study participation. The ordinal regression outcomes evaluated the influences on disinclination, neutrality, and inclination to study participation. RESULTS: Behavioral outcomes such as future recruitment, event attendance, study promotion, and community mobilization did not reveal any differences in participants' intentions between the groups. However, we observed greater interest in HIV vaccine study screening (t = 1.07, P < 0.05) and enrollment (t = 1.15, P < 0.05) following negative vaccine findings. Means on perceptions, attitudes, and beliefs did not differ between the groups. Before this development, only beliefs exhibited a strong relationship on the enrollment intention (β = 2.166, P = 0.002). However, the effect disappeared following negative trial results, with the positive assessment of the study-site perceptions being the only significant contributing factor on enrollment intentions (β = 1.369, P = 0.011). CONCLUSION: Findings show greater enrollment intention among this population in the wake of negative efficacy findings from the Step Study. The resolve of this community to find an HIV vaccine is evident. Moreover, any exposure to information disseminated in the public arena did not appear to negatively influence the potential for future participation in HIV vaccine studies among this population. The results suggest that subsequent studies testing candidate vaccines could be conducted in this population.</p>","PeriodicalId":19500,"journal":{"name":"Open Access Journal of Clinical Trials","volume":"2010 2","pages":"149-156"},"PeriodicalIF":1.4000,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/OAJCT.S11915","citationCount":"9","resultStr":"{\"title\":\"Time will tell: community acceptability of HIV vaccine research before and after the \\\"Step Study\\\" vaccine discontinuation.\",\"authors\":\"Paula M Frew, Mark J Mulligan, Su-I Hou, Kayshin Chan, Carlos del Rio\",\"doi\":\"10.2147/OAJCT.S11915\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>OBJECTIVE: This study examines whether men-who-have-sex-with-men (MSM) and transgender (TG) persons' attitudes, beliefs, and risk perceptions toward human immunodeficiency virus (HIV) vaccine research have been altered as a result of the negative findings from a phase 2B HIV vaccine study. 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引用次数: 9
摘要
目的:本研究探讨男男性行为者(MSM)和变性人(TG)对人类免疫缺陷病毒(HIV)疫苗研究的态度、信念和风险认知是否因2B期HIV疫苗研究的阴性结果而改变。设计:我们对2007年至2008年在亚特兰大社区招募的MSM和TG人群(N = 176)进行了横断面调查。第一组是在一项正在评估候选疫苗的2B期HIV疫苗试验期间招募的(“Step研究”),第二组是在媒体广泛报道产品无效后招募的。方法:采用描述性统计、t检验和卡方检验来确定组间差异,并采用有序logistic回归检验上述因素对关键结局——未来HIV疫苗研究参与情况的影响。序数回归结果评估了不倾向、中立和倾向于研究参与的影响。结果:行为结果,如未来招聘、活动出席、学习促进和社区动员,没有显示组间参与者意图的任何差异。然而,我们观察到,在疫苗结果阴性后,HIV疫苗研究筛选(t = 1.07, P < 0.05)和入组(t = 1.15, P < 0.05)的兴趣更大。在感知、态度和信仰方面,各组之间没有差异。在此之前,只有信念对入组意向有较强的影响(β = 2.166, P = 0.002)。然而,在试验结果为阴性后,这种影响就消失了,对研究地点认知的积极评价是影响入组意向的唯一显著因素(β = 1.369, P = 0.011)。结论:研究结果显示,在Step研究的负面疗效结果之后,该人群的入组意向更大。这个社区寻找艾滋病毒疫苗的决心是显而易见的。此外,接触在公共场所传播的信息似乎不会对这一人群今后参与艾滋病毒疫苗研究的可能性产生负面影响。结果表明,可以在这一人群中进行测试候选疫苗的后续研究。
Time will tell: community acceptability of HIV vaccine research before and after the "Step Study" vaccine discontinuation.
OBJECTIVE: This study examines whether men-who-have-sex-with-men (MSM) and transgender (TG) persons' attitudes, beliefs, and risk perceptions toward human immunodeficiency virus (HIV) vaccine research have been altered as a result of the negative findings from a phase 2B HIV vaccine study. DESIGN: We conducted a cross-sectional survey among MSM and TG persons (N = 176) recruited from community settings in Atlanta from 2007 to 2008. The first group was recruited during an active phase 2B HIV vaccine trial in which a candidate vaccine was being evaluated (the "Step Study"), and the second group was recruited after product futility was widely reported in the media. METHODS: Descriptive statistics, t tests, and chi-square tests were conducted to ascertain differences between the groups, and ordinal logistic regressions examined the influences of the above-mentioned factors on a critical outcome, future HIV vaccine study participation. The ordinal regression outcomes evaluated the influences on disinclination, neutrality, and inclination to study participation. RESULTS: Behavioral outcomes such as future recruitment, event attendance, study promotion, and community mobilization did not reveal any differences in participants' intentions between the groups. However, we observed greater interest in HIV vaccine study screening (t = 1.07, P < 0.05) and enrollment (t = 1.15, P < 0.05) following negative vaccine findings. Means on perceptions, attitudes, and beliefs did not differ between the groups. Before this development, only beliefs exhibited a strong relationship on the enrollment intention (β = 2.166, P = 0.002). However, the effect disappeared following negative trial results, with the positive assessment of the study-site perceptions being the only significant contributing factor on enrollment intentions (β = 1.369, P = 0.011). CONCLUSION: Findings show greater enrollment intention among this population in the wake of negative efficacy findings from the Step Study. The resolve of this community to find an HIV vaccine is evident. Moreover, any exposure to information disseminated in the public arena did not appear to negatively influence the potential for future participation in HIV vaccine studies among this population. The results suggest that subsequent studies testing candidate vaccines could be conducted in this population.