Jordane Biarc, Robert J. Chalkley, A.L. Burlingame, Ralph A. Bradshaw
{"title":"受体酪氨酸激酶信号-蛋白质组学的观点","authors":"Jordane Biarc, Robert J. Chalkley, A.L. Burlingame, Ralph A. Bradshaw","doi":"10.1016/j.advenzreg.2010.10.005","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":7301,"journal":{"name":"Advances in enzyme regulation","volume":"51 1","pages":"Pages 293-305"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.advenzreg.2010.10.005","citationCount":"14","resultStr":"{\"title\":\"Receptor tyrosine kinase signaling – a proteomic perspective\",\"authors\":\"Jordane Biarc, Robert J. Chalkley, A.L. Burlingame, Ralph A. Bradshaw\",\"doi\":\"10.1016/j.advenzreg.2010.10.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":7301,\"journal\":{\"name\":\"Advances in enzyme regulation\",\"volume\":\"51 1\",\"pages\":\"Pages 293-305\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.advenzreg.2010.10.005\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in enzyme regulation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0065257110000774\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in enzyme regulation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0065257110000774","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
摘要
RTKs是介导跨膜信号的最重要家族之一,它们参与并有助于调节广泛的生理活动。实际上,一般来说,酪氨酸激酶及其控制和/或刺激的过程提供了丰富的药物靶点来源,特别是在与生长有关的疾病如癌症中(Zwick等,2002;Krause and Van Etten, 2005)。然而,关于它们的激活和下游信号仍然存在许多问题,而蛋白质组学分析的应用有望回答其中的许多问题。迄今为止,对这种类型的详细研究相对较少,需要更多的研究来更好地定义与主要和次要ptm相关的途径,以及蛋白质-蛋白质相互作用,是指导产生的信号流的手段。我们将采取这样的方法来确定个别家庭的特点,甚至认识到所有家庭在某种程度上都能够激活许多,如果不是全部的主要途径。在高度复杂的细胞内磷酸化网络中(包含数千个修饰位点,显然还没有在任何范例中完全确定),准确地了解哪些激酶修饰哪些底物,并找出与其他修饰(如o - glcnac酰化和乙酰化)的相互关系也是必要的。只有这样,才有可能确定哪些变化具有生理意义,哪些只是背景变化。在此过程中,这些研究应该继续提供潜在的药物靶点,并可能改善目前平淡无奇的生物标志物发现记录。