Understanding and managing peripheral neuropathy.

Peripheral neuropathy is the most common neurological disorder in people with HIV infection. It can be a major source of pain and discomfort and a limiting factor in antiretroviral treatment. Since the introduction of highly active antiretroviral therapy (HAART) in the mid-1990s, the overall incidence of neurological complications of HIV--such as HIV-associated dementia and central nervous system opportunistic infections--has decreased, however, rates of peripheral nervous system complications remain high.