{"title":"g蛋白信号2调节因子遗传变异与新疆哈萨克族高血压的关系","authors":"Nan-Fang Li, Ju-Hong Zhang, Jin Yang, Ling Zhou, Wen-Li Luo, Yan-Ying Guo, Xiao-Guang Yao, Hong-Mei Wang, Jian-Hang Chang","doi":"10.3109/10641960903265253","DOIUrl":null,"url":null,"abstract":"<p><p>Mice deficiency in regulator of G-protein signaling 2(RGS2) showed an evident hypertension phenotype. Here, we studied associations of genetic variations of RGS2 with essential hypertension in the Kazakh population. Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension. A significant association was observed between 1891-1892 TC insertion/deletion with hypertension in men (OR = 1.698, P = 0.03 ) and in total population (OR = 1.32, p = 0.044) in dominant model. The mean systolic blood pressure (SBP) of the ID+DD group was significantly higher than that of the II group (adjusted, p = 0.044). Our results suggest that D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs.</p>","PeriodicalId":286988,"journal":{"name":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","volume":" ","pages":"256-61"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641960903265253","citationCount":"6","resultStr":"{\"title\":\"Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.\",\"authors\":\"Nan-Fang Li, Ju-Hong Zhang, Jin Yang, Ling Zhou, Wen-Li Luo, Yan-Ying Guo, Xiao-Guang Yao, Hong-Mei Wang, Jian-Hang Chang\",\"doi\":\"10.3109/10641960903265253\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mice deficiency in regulator of G-protein signaling 2(RGS2) showed an evident hypertension phenotype. Here, we studied associations of genetic variations of RGS2 with essential hypertension in the Kazakh population. Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension. A significant association was observed between 1891-1892 TC insertion/deletion with hypertension in men (OR = 1.698, P = 0.03 ) and in total population (OR = 1.32, p = 0.044) in dominant model. The mean systolic blood pressure (SBP) of the ID+DD group was significantly higher than that of the II group (adjusted, p = 0.044). Our results suggest that D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs.</p>\",\"PeriodicalId\":286988,\"journal\":{\"name\":\"Clinical and Experimental Hypertension (New York, N.y. : 1993)\",\"volume\":\" \",\"pages\":\"256-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10641960903265253\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Hypertension (New York, N.y. : 1993)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3109/10641960903265253\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Hypertension (New York, N.y. : 1993)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3109/10641960903265253","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
摘要
g蛋白信号传导调节因子2(RGS2)缺乏小鼠表现出明显的高血压表型。在这里，我们研究了哈萨克人群中RGS2遗传变异与原发性高血压的关系。两个鉴定的非同义突变(K18N, Y178C)对高血压没有特异性。在优势模型中，1891-1892 TC插入/缺失与男性高血压(OR = 1.698, P = 0.03)和总体人群(OR = 1.32, P = 0.044)存在显著相关性。ID+DD组的平均收缩压(SBP)显著高于II组(p = 0.044)。结果提示，RGS2 1891-1892 TC的D等位基因插入/缺失可能是新疆哈萨克族高血压的独立危险因素。
Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population.
Mice deficiency in regulator of G-protein signaling 2(RGS2) showed an evident hypertension phenotype. Here, we studied associations of genetic variations of RGS2 with essential hypertension in the Kazakh population. Two identified nonsynonymous mutations (K18N, Y178C) were not specific for hypertension. A significant association was observed between 1891-1892 TC insertion/deletion with hypertension in men (OR = 1.698, P = 0.03 ) and in total population (OR = 1.32, p = 0.044) in dominant model. The mean systolic blood pressure (SBP) of the ID+DD group was significantly higher than that of the II group (adjusted, p = 0.044). Our results suggest that D allele of 1891-1892 TC insertion/deletion of RGS2 might be an independent risk factor for hypertension in Xinjiang Kazakhs.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
