{"title":"抗ccp:量化自身抗体和创建国际参考材料的挑战。","authors":"Michael Rottmann","doi":"10.3109/00365513.2010.493381","DOIUrl":null,"url":null,"abstract":"<p><p>Anti-CCP assays (antibody to cyclic citrullinated peptides) possess a high specificity for RA (rheumatoid arthritis). In lack of an international reference material the absolute values among different assays strongly diversify. The cut-off showed a variance from 5 U/mL Euroimmun anti-CCP to 25 U/mL Euro-Diagnostica Immunosan RA. The Autoantibody Standardization Committee is currently trying to establish a reference specimen of human polyclonal anti-CCP.</p>","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"242 ","pages":"44-5"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2010.493381","citationCount":"5","resultStr":"{\"title\":\"Anti-CCP: challenges in quantifying auto-antibodies and creating international reference materials.\",\"authors\":\"Michael Rottmann\",\"doi\":\"10.3109/00365513.2010.493381\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Anti-CCP assays (antibody to cyclic citrullinated peptides) possess a high specificity for RA (rheumatoid arthritis). In lack of an international reference material the absolute values among different assays strongly diversify. The cut-off showed a variance from 5 U/mL Euroimmun anti-CCP to 25 U/mL Euro-Diagnostica Immunosan RA. The Autoantibody Standardization Committee is currently trying to establish a reference specimen of human polyclonal anti-CCP.</p>\",\"PeriodicalId\":76518,\"journal\":{\"name\":\"Scandinavian journal of clinical and laboratory investigation. Supplementum\",\"volume\":\"242 \",\"pages\":\"44-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/00365513.2010.493381\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of clinical and laboratory investigation. Supplementum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/00365513.2010.493381\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of clinical and laboratory investigation. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/00365513.2010.493381","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-CCP: challenges in quantifying auto-antibodies and creating international reference materials.
Anti-CCP assays (antibody to cyclic citrullinated peptides) possess a high specificity for RA (rheumatoid arthritis). In lack of an international reference material the absolute values among different assays strongly diversify. The cut-off showed a variance from 5 U/mL Euroimmun anti-CCP to 25 U/mL Euro-Diagnostica Immunosan RA. The Autoantibody Standardization Committee is currently trying to establish a reference specimen of human polyclonal anti-CCP.
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