Giovanni Conzo, Francesco Stanzione, Antonietta Palazzo, Umberto Brancaccio, Cristina Della Pietra, Maria Grazia Esposito, Salvatore Celsi, Antonio Livrea
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引用次数: 0
摘要
甲状腺乳头状癌和滤泡癌的生物学和临床行为尚不清楚,自噬发生率高于临床发生率。淋巴结累及是可能增加局部复发率的预后因素,仅在高风险患者(年龄> 45岁,M+, T > 3cm,甲状腺外展,滤泡组织型)中才会降低长期生存率。作者分析了颈淋巴结清扫术的作用。文献中描述了常规或选择性,扩大或保守淋巴切除术。预后因素有助于确定最合适的手术方式。高危患者可择期行颈椎中央淋巴结清扫术,而单侧淋巴结转移病例中,低危患者可择期行VI-III-IV级淋巴结清扫术,其发病率较低。改良根治性颈部清扫术用于高危患者或多发淋巴结转移(> 5)的患者,以减少局部复发的发生率。在分化型甲状腺癌的治疗中,选择性甲状腺全切除术必须与辅助放射性碘消融联合进行。
[Lymphectomy in differentiated thyroid carcinoma].
Papillary and follicular thyroid carcinoma are still characterised by unclear biological and clinical behaviour with an autoptic incidence higher than the clinical incidence. Lymph-node involvement represents a prognostic factor that may increase the rate of local relapse, reducing long-term survival only in high risk patients--age > 45 years, M+, T > 3 cm, extra thyroidal extension, follicular histotype. The authors analyse the role of lymph-node cervical dissection. Routine or selective, extended or conservative lymphectomy are described in the literature. Prognostic factors are useful to determine the most appropriate surgical procedure. An elective cervical central dissection may be indicated in patients at high risk, while in cases of monolateral lymph-node metastases, in patients at low risk, a selective lymph node dissection of levels VI-III-IV is associated with lower morbidity. Modified radical neck dissection is reserved for patients at high risk or in cases of multiple lymph-node metastases (> 5) to reduce the incidence of local relapse. In the treatment of differentiated thyroid carcinoma an elective total thyroidectomy must be performed in combination with adjuvant radioiodine ablation.