Vijay Ns Bhagawati-Prasad, Evy De Leenheer, Nadine P Keefe, Lorna A Ryan, Jennifer Carlring, Andrew W Heath
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CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
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