作为强效 iNOS 二聚化抑制剂的咪唑嘧啶衍生物的设计与合成。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2009-11-18 DOI:10.2174/1874104500903010008

Guo-Hua Chu, Bertrand Le Bourdonnec, Minghua Gu, Christopher W Ajello, Lara K Leister, Ian Sellitto, Joel A Cassel, Paul A Tuthill, Heather O' Hare, Robert N Dehaven, Roland E Dolle

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引用次数: 0

摘要

我们合成了一系列通式为 I 的咪唑嘧啶衍生物，并确定它们是 iNOS 二聚体形成的强效抑制剂，而 iNOS 二聚体的形成是该酶正常工作的前提条件。Stille 和 Negishi 偶联反应是形成连接咪唑嘧啶核心与中央环烯基、环烷基和苯基环模板的碳-碳键的关键步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.

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Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.

A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量