血管内皮生长因子(VEGF)对应激性胃粘膜溃疡大鼠胃保护作用的影响。

Methods and findings in experimental and clinical pharmacology Pub Date : 2009-10-01 DOI:10.1358/mf.2009.31.8.1419716

J Wozniak-Holecka, J Josko, M Tyrpien, J Kasperczyk, K Steplewska, T Holecki

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引用次数: 8

摘要

在进化过程中，形成了许多复杂的保护胃粘膜的机制，如血管生成和刺激粘膜生长等。本研究的目的是确定血管内皮生长因子(VEGF)腹腔注射在应激性急性胃溃疡大鼠胃保护反应中的作用。当应激暴露前24小时注射VEGF时，观察到血管数量急剧增加。应用VEGF后胃液分泌、溃疡深度及溃疡指数明显降低。结果表明VEGF对应激性溃疡具有胃保护作用。

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Influence of vascular endothelial growth factor (VEGF) on gastroprotection in stress-induced gastric mucosal ulcers in rats.

In the process of evolution a number of complicated mechanisms have developed to protect the gastric mucous membrane, e.g., angiogenesis and stimulation of mucosal growth. The aim of this study was to determine the role of vascular endothelial growth factor (VEGF) administered intraperitoneally in the gastroprotective response to stress-induced acute gastric ulcers in rats. A dramatic increase in the number of blood vessels was observed when VEGF was injected 24 h before stress exposure. Gastric secretion, depth of ulceration and ulceration index decreased significantly after VEGF application. The results demonstrate the gastroprotective effect of VEGF on stress-induced ulceration.

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来源期刊

Methods and findings in experimental and clinical pharmacology 医学-药学

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>12 weeks