{"title":"药物合成中的替代无溶剂方法。","authors":"William C Shearouse, Daniel C Waddell, James Mack","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.</p>","PeriodicalId":10809,"journal":{"name":"Current opinion in drug discovery & development","volume":"12 6","pages":"772-83"},"PeriodicalIF":0.0000,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs.\",\"authors\":\"William C Shearouse, Daniel C Waddell, James Mack\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.</p>\",\"PeriodicalId\":10809,\"journal\":{\"name\":\"Current opinion in drug discovery & development\",\"volume\":\"12 6\",\"pages\":\"772-83\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in drug discovery & development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in drug discovery & development","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs.
Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.
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