胸苷激酶:丢失的化疗靶点。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp142

Mahmoud Kandeel, Aya Kato, Yoshiaki Kitamura, Yukio Kitade

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引用次数: 9

摘要

在这里，我们强调了恶性疟原虫胸苷激酶(PfTMK)不同寻常的底物特异性，以及该酶作为新的药物靶点的有效性。此外，我们预测无原体边缘酶具有吸引域成分，可能在功能上不同于其他tmpk。我们推测胸苷酸激酶可能在病原体中具有多种吸引人的功能，并可能成为对抗多种微生物的新药物靶点。

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Thymidylate kinase: the lost chemotherapeutic target.

Here we highlight the unusual substrate specificity of Plasmodium falciparum thymidylate kinase (PfTMK) and the validity of the enzyme as a new drug target. Furthermore, we predict that the Anaplasma marginale enzyme has attractive domain constituents and may be functionally different from other TMPKs. We postulate that thymidylate kinases could have multiple attractive functions in pathogens and may be a new drug target against numerous microorganisms.

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Nucleic acids symposium series (2004)

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