[食道肿瘤的手术治疗:基于治疗结果的考虑]。

Chirurgia italiana Pub Date : 2009-07-01
Alessandro Longhini, Francesco Della Nave, Alessandro Grechi, Amir Reza Kazemian, Gianluca Munarini, Giuseppe Marcolli
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引用次数: 0

摘要

在过去的二十年中,食管癌虽然被认为是最恶性的内脏肿瘤之一,但手术后的远距离生存率逐渐增加。本研究的目的是介绍我们的手术方法的结果,并在此基础上讨论有关采取干预措施的一些考虑因素。在一项回顾性研究中,我们在Sondrio市立医院普通外科招募了105例食管癌患者,他们接受了各种类型的食管切除术,有或没有开胸。术后死亡率为12%,非致死性并发症发生率为40.2%。无论患者是否为R0,平均总生存期为31.2个月(范围:1-167),精算生存率为1年63.2%,3年30.3%,5年22.1%。这与手术类型、肿瘤的位置或组织学没有明显关系,而TNM分期、顶骨浸润程度和有无淋巴结转移是重要因素。虽然我们将淋巴结切除术限制为“标准或扩展的双野”手术,但我们5年的总体生存率与主张更广泛的淋巴结切除术的外科医生相似。在我们的病例中,大多数复发发生在全身水平和短期内,平均在12.7个月后,这意味着微转移可能在干预时已经存在(事实上,这些患者中有82.4%为N1期癌症)。我们更倾向于颈吻合术,因为它有可能提供更大的食管切除,并且在裂口的情况下相对安全。我们总是进行右颈切开术,这使我们避免了在手术台上移动病人,也减少了对复发神经的伤害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Surgical approach in the management of oesophageal tumours: considerations based on therapeutic results].

Over the last two decades, oesophageal cancers, although considered among the most malignant visceral tumours, have witnessed a gradual increase in survival rates at a distance after surgery. The aims of the study were to present the results of our surgical approach and, on this basis, to discuss a number of considerations regarding the type of intervention to be adopted. In a retrospective study we recruited 105 patients with oesophageal cancer treated with various types of oesophageal resection, with or without thoracotomy, in the Division of General Surgery of the Civic Hospital of Sondrio. The postoperative mortality rate was 12%, with 40.2% of non-lethal complications. The average overall survival, whether in patients R0 or not, was 31.2 months (range: 1-167), with actuarial survival rates of 63.2% at one year, 30.3% at three years and 22.1% at five years. This was not significantly influenced by the type of surgery or by the location or histology of the cancer, while TNM stage, degree of parietal infiltration and the presence or absence of lymph-node metastases were significant factors. Although we limited the lymphadenectomy to "standard or extended two-field" operations, our overall survival at five years was similar to that of surgeons advocating much more extensive lymphadenectomy. In our case most of the relapses occurred at the systemic level and in the short term, on average after 12.7 months, meaning that micrometastases were probably already present at the time of intervention (82.4% of these patients, in fact, had stage N1 cancers). We prefer cervical anastomosis owing to the possibility it affords of greater oesophageal resection and to its relative safety in case of dehiscence. We always perform a right cervicotomy, which allows us to avoid having to move the patient on the operating table and to have fewer injuries to the recurrent nerve.

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