Photo-controllable适体。

Shinzi Ogasawara, Mizuo Maeda
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引用次数: 3

摘要

我们已经成功地开发了一种利用光致变色核碱基(8FV)G的顺反光异构化来光调控G-四聚体形成的新方法。我们的光可控四重体可以在非常稳定的四重体状态和非结构化状态之间以直接和可逆的方式切换。我们还证明了g -四重体与凝血酶的可逆控制结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photo-controllable aptamer.

We have successfully developed a new method for photoregulation of G-quadruplex formation using cis-trans photoisomerization of the photochromic nucleobase (8FV)G. Our photo-controllable quadruplexes can be switched between a very stable quadruplex state and a non-structured state in a straightforward and reversible fashion. We also demonstrated reversibly control binding of a G-quadruplex aptamer to thrombin.

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