接吻环RNA二聚体上多胺的对接模拟。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp137

Misaki Imai, Daisuke Chikatsu, Emire Inomata, Tairo Oshima, Gota Kawai

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引用次数: 6

摘要

多胺，特别是支化多胺，如四(3-氨基丙基)铵(Taa)，稳定RNA分子的三级结构。在这项研究中，我们通过对接模拟检测了接吻环二聚体中HIV-1二聚化起始位点(DIS)的多胺结合位点。结果发现Taa主要结合在DIS的接吻环相互作用位点。

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Docking simulation of polyamines on a kissing-loop RNA dimer.

Polyamines, especially branched polyamines such as tetrakis(3-aminopropyl)ammonium (Taa), stabilize the tertiary structure of RNA molecules. In this study, we examined the polyamine binding site of the HIV-1 dimerization initiation site (DIS) in the kissing-loop dimer by the docking simulation. It was found that Taa binds predominantly to the kissing loop interaction site of DIS.

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Nucleic acids symposium series (2004)

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