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引用次数: 41
摘要
位于白细胞介素-7受体α链(IL7RA)的单核苷酸多态性(SNP) rs6897932的C等位基因最近被发现与多发性硬化症和I型糖尿病有关。我们分析了慢性炎性关节病(类风湿关节炎和幼年特发性关节炎;368名患者和532名未受影响的受试者)。除非同义SNP rs6897932外，未发现与疾病有显著关联。与对照组相比，该SNP显示关节炎患者TT基因型适度富集[P = 0.02;或1.72 (95% ci 1.08-2.75)]。我们的数据提示rs6897932在慢性炎性关节病易感性中的作用。
IL7RA polymorphisms and chronic inflammatory arthropathies.
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
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