肿瘤基因治疗载体发展展望。

Gene Therapy and Molecular Biology Pub Date : 2009-01-01
Arash Hatefi, Brenda F Canine
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引用次数: 0

摘要

基因疗法被认为是一项革命性的技术,只要我们了解其遗传基础,就有望治愈几乎所有疾病。然而,由于多次临床试验未能显示出疗效,人们的热情迅速消退。限制因素似乎是缺乏合适的递送系统,以安全有效地将治疗基因携带到靶组织。因此,癌症基因治疗的进展通常依赖于新型载体的发展,这些载体在靶部位具有最大的治疗效果,对正常组织的毒性最小。这篇小型综述强调了目前用于癌症基因治疗的最先进基因载体的主要优点和独特挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perspectives in vector development for systemic cancer gene therapy.

Gene therapy is perceived as a revolutionary technology with the promise to cure almost any disease, provided that we understand its genetic basis. However, enthusiasm has rapidly abated as multiple clinical trials have failed to show efficacy. The limiting factor seems to be the lack of a suitable delivery system to carry the therapeutic genes to the target tissue safely and efficiently. Therefore, advancements in cancer gene therapy in general depend on the development of novel vectors with maximum therapeutic efficacy at the target site and minimal toxicity to normal tissues. This mini-review highlights both the major fortes and the unique challenges associated with the state-of-the-art gene carriers currently being used in cancer gene therapy.

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来源期刊
Gene Therapy and Molecular Biology
Gene Therapy and Molecular Biology 生物-生化与分子生物学
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