北印度地区TNFRSF1B多态性与2型糖尿病及其相关性状的关联分析

IF 3.5 Q1 EDUCATION & EDUCATIONAL RESEARCH
Genomic medicine Pub Date : 2008-12-01 Epub Date: 2009-04-03 DOI:10.1007/s11568-009-9031-7
Rubina Tabassum, Sreenivas Chavali, Anubha Mahajan, Saurabh Ghosh, S V Madhu, Nikhil Tandon, Dwaipayan Bharadwaj
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引用次数: 15

摘要

炎症在2型糖尿病的发病机制中起着至关重要的作用,各种证据表明2型受体TNFR2(一种炎症反应的介质)的重要贡献。虽然TNFRSF1B(编码TNFR2)多态性的遗传关联已经在各种研究中进行了研究,但由于研究结果不一致,它们的参与尚不清楚。由于印度人群对2型糖尿病及其并发症的高易感性,我们评估了TNFRSF1B多态性-rs1061622 (M196R;外显子6)和rs3397 (3'UTR)和(CA)(n)重复(内含子4)在1852名受试者中发现,其中包括1040例和812例对照的北印度印欧种族2型糖尿病及其相关周围神经病变和高血压患者。这些多态性的等位基因和基因型分布在健康对照组与2型糖尿病、周围神经病变组与非神经病变组、高血压组与正常血压组之间具有可比性。(CA)(n)多态性已被证明与白种人的糖尿病神经病变有关,然而,在我们的研究中无法重复这一点(P = 0.27)。未发现任何多态性影响与2型糖尿病相关的14个人体测量和生化性状。因此,我们得出结论,TNFRSF1B不是北印度人2型糖尿病、相关周围神经病变、高血压和相关代谢特征遗传风险的主要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India.

Inflammation plays a crucial role in the pathogenesis of type 2 diabetes and various lines of evidences suggest an important contribution of type 2 receptor for TNFalpha (TNFR2), a mediator of inflammatory responses. Though genetic association of TNFRSF1B (encoding TNFR2) polymorphisms have been investigated in various studies, their involvement is not clear because of inconsistent findings. Because of high susceptibility of Indian population to type 2 diabetes and its complications, we evaluated the association of TNFRSF1B polymorphisms-rs1061622 (M196R; exon6) and rs3397 (3'UTR) and (CA)( n ) repeat (intron 4) in 1,852 subjects including 1,040 cases and 812 controls with type 2 diabetes and its associated peripheral neuropathy and hypertension in North Indians of Indo-European ethnicity. The allelic and genotypic distributions of these polymorphisms were comparable among healthy control vs. type 2 diabetes, peripheral neuropathy vs. non-neuropathy and hypertensive vs. normotensive groups. (CA)( n ) polymorphism has been shown to be associated with diabetic neuropathy in Caucasians, however, this could not be replicated in our study (P = 0.27). None of the polymorphisms were found to influence the 14 anthropometric and biochemical traits related to type 2 diabetes studied here. Thus, we conclude that TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians.

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