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引用次数: 0
摘要
亚硝酸过氧化物（PN）由一氧化氮（NO）和超氧化物反应生成，是生物学中最快速的反应之一。研究报告称，过氧化亚硝酸盐是一种细胞毒性分子，在多种疾病状态下会导致血管损伤。不过，PN 显然具有有益的作用，包括扩张血管、抑制血小板聚集、抑制炎症细胞粘附以及防止心脏缺血/再灌注损伤。我们的假设是，PN 可使超氧化物失活，延长 NO 在循环中的作用时间。本手稿回顾了 PN 对心血管系统的有益作用。
Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of platelet aggregation, inhibition of inflammatory cell adhesion, and protection against ischemia/reperfusion injury in the heart. It is our hypothesis that PN may serve to inactivate superoxide and prolong the actions of NO in the circulation. This manuscript reviews the beneficial effects of PN in the cardiovascular system.
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