量化年轻心肌动态电不稳定性的心电图恢复像。

Computers in cardiology Pub Date : 2007-01-01
Ja Bell, Nc Rouze, W Krassowska, Sf Idriss
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引用次数: 0

摘要

需要开发新的方法来检测儿童的电不稳定性。动作电位恢复的动力学特性在心律失常的不稳定性发展中起重要作用。一种新的方法,恢复画像(RP),发展可视化和量化这些性质在动作电位水平。在这里,我们应用RP方法,利用心电图的激活恢复间隔(ARI)来检测新生儿和青春期前患有药物性长QT综合征(LQTS 1型或2型)的兔心肌的复极异常。在程序性心内膜起搏期间记录心电图以记录RP。与基线相比,在药物诱导的LQTS期间,ECG RP显示出动态恢复成分的显著变化。这项研究表明,心电图RP可能是一种重要的无创诊断工具,用于检测年轻人的电不稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Electrocardiogram Restitution Portrait Quantifying Dynamical Electrical Instability in Young Myocardium.

Novel methods need to be developed to detect electrical instability in children. The dynamical properties of action potential restitution play an important role in the development of instability leading to arrhythmias. A new method, the Restitution Portrait (RP), was developed to visualize and quantify these properties at the action potential level. Here, we apply the RP method using the activation-recovery interval (ARI) from the ECG to detect, in vitro, repolarization abnormalities in neonatal and preadolescent rabbit myocardium with drug-induced Long QT Syndrome (LQTS Type 1 or Type 2). The ECG was recorded during programmed endocardial pacing to record the RP. The ECG RP demonstrated significant changes in dynamical restitution components during drug-induced LQTS compared to baseline. This study shows that the ECG RP may be an important noninvasive diagnostic tool for detecting electrical instability in the young.

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