澳大利亚轮状病毒监测计划的评价。

April R Roberts-Witteveen, Mahomed S Patel, Paul W Roche
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摘要

澳大利亚轮状病毒血清分型计划(ARSP)从澳大利亚实验室送出的粪便样本中分离的轮状病毒血清分型。澳大利亚政府卫生和老龄部与ARSP合作,对该方案的效用和监测最近纳入澳大利亚国家免疫方案的轮状病毒疫苗有效性的能力进行了评估。使用ARSP年度报告和工作人员访谈来描述该系统。通过采用评估监测系统的标准准则来评估该系统的属性。对ARSP的工作人员、参与的实验室、轮状病毒疫苗生产公司和澳大利亚传染病网络的代表进行了电子邮件调查或面对面访谈。评估了ARSP监测轮状病毒血清型流行病学变化的能力。至少每两年从参与实验室收到ARSP血清型轮状病毒分离株,报告结果的频率至少相同。血清型分析为轮状病毒疫苗的制定提供了信息,并有助于预测由新型血清型引起的疫情的程度。ARSP将能够监测轮状病毒血清型流行病学的变化,并确定可能的疫苗接种失败。需要提高该系统的代表性和敏感性,使数据在公共卫生方面仍然有用。需要制定在方案与州和地区卫生部门之间传输数据的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An evaluation of the Australian Rotavirus Surveillance Program.

The Australian Rotavirus Serotyping Program (ARSP) serotypes rotavirus isolates obtained from stool samples sent from Australian laboratories. In collaboration with ARSP the Australian Government Department of Health and Ageing evaluated the program for its utility and capacity to monitor effectiveness of the rotavirus vaccines recently introduced into the Australian National Immunisation Program. The system was described using ARSP annual reports and staff interviews. The attributes of the system were assessed by adapting standard guidelines for evaluating a surveillance system. Email surveys or face to face interviews were conducted with staff of ARSP, participating laboratories, rotavirus vaccine manufacturing companies and representatives of the Communicable Diseases Network Australia. The ability of the ARSP to monitor changes in rotavirus serotype epidemiology was assessed. ARSP serotypes rotavirus isolates received from participating laboratories at least bi-annually, with results being reported at least as often. Serotype analyses have informed formulation of rotavirus vaccines and contributed to forecasting the extent of outbreaks caused by novel serotypes. The ARSP will be able to monitor changes in rotavirus serotype epidemiology and identify probable vaccination failures. Enhancement of the representativeness and sensitivity of the system are needed for the data to remain useful in the public health context. Methods for transferring data between the program and state and territory health departments need to be developed.

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