{"title":"维生素D在治疗皮肤结核中的作用。","authors":"G B DOWLING","doi":"10.1111/j.1365-2133.1948.tb11008.x","DOIUrl":null,"url":null,"abstract":"phate ions from phosphoric esters. The increase of available phosphate ions is of great importance. The Americans, Schapiro and Wertheimer, have demonstrated in many animal tissues a ferment which acts on the phospholipides and destroys the higher fatty acids. This ferment requires for its activity the presence of phosphate radicals and muscle adenjdic acid. It is inactivated by oxygen. Koch's bacillus is particularly rich in lipoids of great complexity, waxes as well as fatty acids, both free and in combination as phosphatides. It seemed possible that some such ferment might have some lytic action on the tubercle baciUus, and might he activated by phosphate ions made available by vitamin D. It was desirable therefore to investigate the action of added adenylic acid on the therapeutic properties of vitamin D. This I was able to accomplish in a case of extensive tuberculous ulceration in which the combination of vitamin Dg with local application of adenylic acid resulted in the disappearance within a few hours of all tubercle bacilli from the lesion. Perhaps the failure in pulmonary tuberculosis is due to the inhibition of the ferment by the high oxygen tension.","PeriodicalId":55324,"journal":{"name":"British Journal of Dermatology and Syphilis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1948-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2133.1948.tb11008.x","citationCount":"8","resultStr":"{\"title\":\"Vitamin D in the treatment of cutaneous tuberculosis.\",\"authors\":\"G B DOWLING\",\"doi\":\"10.1111/j.1365-2133.1948.tb11008.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"phate ions from phosphoric esters. The increase of available phosphate ions is of great importance. The Americans, Schapiro and Wertheimer, have demonstrated in many animal tissues a ferment which acts on the phospholipides and destroys the higher fatty acids. This ferment requires for its activity the presence of phosphate radicals and muscle adenjdic acid. It is inactivated by oxygen. Koch's bacillus is particularly rich in lipoids of great complexity, waxes as well as fatty acids, both free and in combination as phosphatides. It seemed possible that some such ferment might have some lytic action on the tubercle baciUus, and might he activated by phosphate ions made available by vitamin D. It was desirable therefore to investigate the action of added adenylic acid on the therapeutic properties of vitamin D. This I was able to accomplish in a case of extensive tuberculous ulceration in which the combination of vitamin Dg with local application of adenylic acid resulted in the disappearance within a few hours of all tubercle bacilli from the lesion. Perhaps the failure in pulmonary tuberculosis is due to the inhibition of the ferment by the high oxygen tension.\",\"PeriodicalId\":55324,\"journal\":{\"name\":\"British Journal of Dermatology and Syphilis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1948-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1365-2133.1948.tb11008.x\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Journal of Dermatology and Syphilis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/j.1365-2133.1948.tb11008.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Dermatology and Syphilis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1365-2133.1948.tb11008.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Vitamin D in the treatment of cutaneous tuberculosis.
phate ions from phosphoric esters. The increase of available phosphate ions is of great importance. The Americans, Schapiro and Wertheimer, have demonstrated in many animal tissues a ferment which acts on the phospholipides and destroys the higher fatty acids. This ferment requires for its activity the presence of phosphate radicals and muscle adenjdic acid. It is inactivated by oxygen. Koch's bacillus is particularly rich in lipoids of great complexity, waxes as well as fatty acids, both free and in combination as phosphatides. It seemed possible that some such ferment might have some lytic action on the tubercle baciUus, and might he activated by phosphate ions made available by vitamin D. It was desirable therefore to investigate the action of added adenylic acid on the therapeutic properties of vitamin D. This I was able to accomplish in a case of extensive tuberculous ulceration in which the combination of vitamin Dg with local application of adenylic acid resulted in the disappearance within a few hours of all tubercle bacilli from the lesion. Perhaps the failure in pulmonary tuberculosis is due to the inhibition of the ferment by the high oxygen tension.