2005年澳大利亚分离肠球菌抗微生物药物耐药性流行情况:澳大利亚抗微生物药物耐药性小组报告

Keryn J Christiansen, John D Turnidge, Jan M Bell, Narelle M George, Julie C Pearson
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引用次数: 0

摘要

2005年在一项点流行研究中检查了引起临床疾病的肠球菌的抗生素耐药性。澳大利亚22个站点连续收集了多达100个分离株,并使用标准化方法检测了它们对氨苄西林、万古霉素、高水平庆大霉素和/或高水平链霉素的敏感性。结果与1995年、1999年和2003年进行的类似调查进行了比较。在2005年的调查中,粪肠球菌(1987株)和粪肠球菌(180株)占检测的2197株分离物的98.6%。氨苄西林耐药性在粪肠杆菌中很常见(77%),但在粪肠杆菌中仍很少见(0.2%)。对万古霉素的耐药率分别为7.2%和0.2%;所有万古霉素耐药菌株均检测到vanB基因。对庆大霉素高度耐药的粪肠杆菌占35.8%,粪肠杆菌占52.2%;链霉素高水平耐药率分别为10.3%和60.2%。与1995年、1999年和2003年澳大利亚抗菌素耐药性小组调查相比,肠球菌中万古霉素耐药和庆大霉素高水平耐药的比例正在增加。了解澳大利亚万古霉素耐药肠球菌和高水平氨基糖苷耐药的发生情况对指导感染控制实践、抗生素处方政策和药物监管决策具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of antimicrobial resistance in Enterococcus isolates in Australia, 2005: report from the Australian Group on Antimicrobial Resistance.

Antibiotic resistance in Enterococcus species causing clinical disease was examined in a point-prevalence study in 2005. Twenty-two sites around Australia collected up to 100 consecutive isolates and tested them for susceptibility to ampicillin, vancomycin, high-level gentamicin and/or high-level streptomycin using standardised methods. Results were compared to similar surveys conducted in 1995, 1999 and 2003. In the 2005 survey, Enterococcus faecalis (1,987 strains) and E. faecium (180 strains) made up 98.6% of the 2,197 isolates tested. Ampicillin resistance was common (77%) in E. faecium, but rare still in E. faecalis (0.2%). Resistance to vancomycin was 7.2% in E. faecium and 0.2% in E. faecalis; the vanB gene was detected in all vancomycin-resistant isolates. High-level resistance to gentamicin was 35.8% in E. faecalis and 52.2% in E. faecium; the figures for high-level streptomycin resistance were 10.3% and 60.2% respectively. Compared to previous Australian Group on Antimicrobial Resistance surveys in 1995, 1999 and 2003, the proportions of vancomycin resistance and high-level gentamicin resistance in enterococci are increasing. It is important to have an understanding of the occurrence of vancomycin resistant enterococci and high level aminoglycoside resistance in Australia to guide infection control practices, antibiotic prescribing policies and drug regulatory decisions.

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