植物源性化合物的药物发现与开发。

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques Pub Date : 2008-01-01 DOI:10.1007/978-3-7643-8117-2_2

Olivier Potterat, Matthias Hamburger

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引用次数: 73

摘要

综述了目前基于植物源性天然产物的药物开发工作。重点是已经进入临床发展阶段的项目。治疗领域包括癌症、包括艾滋病毒在内的病毒感染、疟疾、炎症性疾病、伤害和疫苗佐剂、代谢紊乱和神经退行性疾病。还讨论了基于植物的药物发现和开发的特定方面，例如商业开发中的供应问题和《生物多样性公约》。

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Drug discovery and development with plant-derived compounds.

An overview is given on current efforts in drug development based on plant-derived natural products. Emphasis is on projects which have advanced to clinical development. Therapeutic areas covered include cancer, viral infections including HIV, malaria, inflammatory diseases, nociception and vaccine adjuvants, metabolic disorders, and neurodegenerative diseases. Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity.

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Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques

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