综述:基于蛋白质的生物材料在血管组织工程中的研究进展。

Jan P Stegemann, Stephanie N Kaszuba, Shaneen L Rowe
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引用次数: 196

摘要

临床需要改进的血管替代品,特别是在小直径的应用,推动了血管组织工程领域。血管具有很好的结构和功能特征,但它是一个复杂的组织,并且已经证明很难创建适合广泛临床使用的工程组织。本文综述了利用蛋白质作为主要基质或“支架”材料来制造完全生物血管替代物的血管组织工程方法。本文特别综述了血管组织工程的四种主要方法:1)细胞填充蛋白水凝胶,2)交联蛋白支架,3)脱细胞原生组织,4)自组装支架。讨论了这些领域的最新进展,以及这些方法的优点和缺点。第一个完全的生物工程血管已经进入临床试验,但在工程血管组织具有广泛的临床效果之前,仍然存在重要的挑战。细胞来源和再现天然血管的生物和机械功能仍然是重要的突出障碍。此外,必须更好地界定这类组织的商业化道路。在血管替代品能够充分发挥其改善患者护理的潜力之前,血管组织工程的几种互补方法的持续进展是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review: advances in vascular tissue engineering using protein-based biomaterials.

The clinical need for improved blood vessel substitutes, especially in small-diameter applications, drives the field of vascular tissue engineering. The blood vessel has a well-characterized structure and function, but it is a complex tissue, and it has proven difficult to create engineered tissues that are suitable for widespread clinical use. This review is focused on approaches to vascular tissue engineering that use proteins as the primary matrix or "scaffold" material for creating fully biological blood vessel replacements. In particular, this review covers four main approaches to vascular tissue engineering: 1) cell-populated protein hydrogels, 2) cross-linked protein scaffolds, 3) decellularized native tissues, and 4) self-assembled scaffolds. Recent advances in each of these areas are discussed, along with advantages of and drawbacks to these approaches. The first fully biological engineered blood vessels have entered clinical trials, but important challenges remain before engineered vascular tissues will have a wide clinical effect. Cell sourcing and recapitulating the biological and mechanical function of the native blood vessel continue to be important outstanding hurdles. In addition, the path to commercialization for such tissues must be better defined. Continued progress in several complementary approaches to vascular tissue engineering is necessary before blood vessel substitutes can achieve their full potential in improving patient care.

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来源期刊
Tissue engineering
Tissue engineering CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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