衣原体交互数据库,用于交叉查询基因组学、转录组学和蛋白质组学数据

Yan Chen , Peter Timms , Yi-Ping Phoebe Chen
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引用次数: 7

摘要

衣原体是人类、鸟类和许多动物的重要病原体。它们是一组独特的细菌,其特点是它们的发育周期。衣原体由于其固有的细胞内生长习惯和缺乏遗传转化系统而一直难以研究。然而,在过去的5年中,人们对7株衣原体进行了全基因组测序,并对这些病原体进行了基因组学、转录组学(RT-PCR、微阵列)和蛋白质组学分析。这里描述的衣原体交互数据库(CIDB)是同类数据库中第一个包含基因组、RT-PCR、微阵列和蛋白质组学数据集的数据库,研究人员可以交叉查询这些数据的模式。将多个研究组的数据整合到一个单一的数据库中,并从不同的角度进行交叉查询,将增强我们对这些病原体复杂的细胞生物学的理解。该数据库可在http://www3.it.deakin.edu.au:8080/CIDB/上获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CIDB: Chlamydia Interactive Database for cross-querying genomics, transcriptomics and proteomics data

Chlamydiae are important pathogens of humans, birds and a wide range of animals. They are a unique group of bacteria, characterized by their developmental cycle. Chlamydia has been difficult to study because of their obligate intracellular growth habit and lack of a genetic transformation system. However, the past 5 years has seen the full genome sequencing of seven strains of Chlamydia and a rapid expansion of genomic, transcriptomic (RT-PCR, microarray) and proteomic analysis of these pathogens. The Chlamydia Interactive Database (CIDB) described here is the first database of its type that holds genomic, RT-PCR, microarray and proteomics data sets that can be cross-queried by researchers for patterns in the data. Combining the data of many research groups into a single database and cross-querying from different perspectives should enhance our understanding of the complex cell biology of these pathogens. The database is available at: http://www3.it.deakin.edu.au:8080/CIDB/.

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