N. Tabary , S. Lepretre , F. Boschin , N. Blanchemain , C. Neut , E. Delcourt-Debruyne , B. Martel , M. Morcellet , H.F. Hildebrand
{"title":"含碳水化合物衍生物的PVDF膜功能化以控制氯己定的递送","authors":"N. Tabary , S. Lepretre , F. Boschin , N. Blanchemain , C. Neut , E. Delcourt-Debruyne , B. Martel , M. Morcellet , H.F. Hildebrand","doi":"10.1016/j.bioeng.2007.07.007","DOIUrl":null,"url":null,"abstract":"<div><p>Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18<!--> <!-->wt% increase of the supports. MX grafted membrane could capture 103<!--> <!-->mg/g chlorhexidin digluconate (DigCHX) instead of 1<!--> <!-->mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. <em>In vitro</em> release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and β-CD grafted membranes. The antimicrobial activity was effective during more than 72<!--> <!-->h.</p></div>","PeriodicalId":80259,"journal":{"name":"Biomolecular engineering","volume":"24 5","pages":"Pages 472-476"},"PeriodicalIF":0.0000,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bioeng.2007.07.007","citationCount":"35","resultStr":"{\"title\":\"Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin\",\"authors\":\"N. Tabary , S. Lepretre , F. Boschin , N. Blanchemain , C. Neut , E. Delcourt-Debruyne , B. Martel , M. Morcellet , H.F. Hildebrand\",\"doi\":\"10.1016/j.bioeng.2007.07.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18<!--> <!-->wt% increase of the supports. MX grafted membrane could capture 103<!--> <!-->mg/g chlorhexidin digluconate (DigCHX) instead of 1<!--> <!-->mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. <em>In vitro</em> release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and β-CD grafted membranes. The antimicrobial activity was effective during more than 72<!--> <!-->h.</p></div>\",\"PeriodicalId\":80259,\"journal\":{\"name\":\"Biomolecular engineering\",\"volume\":\"24 5\",\"pages\":\"Pages 472-476\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bioeng.2007.07.007\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomolecular engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1389034407000809\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomolecular engineering","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1389034407000809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin
Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate (DigCHX) instead of 1 mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and β-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
