微绒毛包涵性疾病:进行性粘膜病理。扫描电镜和透射电镜研究,并对可能的发病机制的思考。

J R Poley
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引用次数: 0

摘要

一例非裔美国婴儿在刚出生时出现分泌性腹泻,病因为微绒毛包涵性疾病(MID)。6周龄小肠黏膜活检可通过电镜诊断为MID, 15个月时小肠重复活检显示这种疾病似乎持续发展,小肠黏膜的正常结构和组织不再可识别。由于孩子不能忍受任何形式的肠内营养,小肠移植被考虑,但不能做。由于严重的败血症,患者无法存活,导致多器官衰竭。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microvillus inclusion disease: progressive mucosal pathology. A scanning and transmission electron microscopic study, and thoughts about possible pathogenesis.

An infant of African-American descent presented in the immediate newborn period with secretory diarrhea, the cause of which turned out to be microvillus inclusion disease (MID). Small intestinal mucosal biopsies at 6 weeks of age were diagnostic for MID by electron microscopy and repeat biopsies from the small intestine at 15 months demonstrated the seeming relentless progression of this disorder, when a normal structure and organization of small intestinal mucosa was no longer recognizable. Since the child could not tolerate any form of enteral nutrition, a small intestinal transplant was contemplated, but could not be done. The patient did not survive the consequences of an overwhelming sepsis, which resulted in multi-organ failure.

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