婴儿非惊厥性癫痫持续状态的一种形式是心律失常吗?

A L Lux
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摘要

背景:低心律失常通常与婴儿痉挛有关,这种组合被称为韦斯特综合征。低心律失常是否被有效地视为非惊厥性癫痫持续状态(NCSE)的一种形式是有争议的。摘要:心律失常最早的英语描述报告了几乎连续的脑电图模式,尽管后来的研究显示了一定程度的状态依赖。其主要特征是非常高的振幅和不规则的慢波叠加多灶性癫痫样放电。痉挛发作明显是明显的癫痫发作事件,与痉挛发作相关的脑电图变化模式。关于心律失常的定义界限和NCSE的定义特征仍然存在争议。有证据表明,心律失常是一种随年龄发展的脑电图模式,有时独立于临床特征。通常,心律失常与神经发育技能的延迟或退化有关,最近的研究报道,较长的诊断和有效治疗时间与较差的长期神经发育结果相关。最近对NCSE的共识定义和分类提出了允许将心律失常纳入NCSE脑电图模式的界限。在实践中,接受心律失常是NCSE的一种形式的观点,可能会导致对有轻微发育迟缓或倒退的婴儿进行更早的适当调查,从而避免治疗延误,并潜在地保留发育潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is hypsarrhythmia a form of non-convulsive status epilepticus in infants?

Background: Hypsarrhythmia is generally associated with infantile spasms, a combination referred to as West syndrome. It is debatable whether hypsarrhythmia is usefully regarded as a form of non-convulsive status epilepticus (NCSE).

Summary points: The earliest English language description of hypsarrhythmia reported an almost continuous EEG pattern, although later studies showed a degree of state dependence. Its principal features are very high amplitude and irregular slow waves with superimposed multifocal epileptiform discharges. Paroxysms of spasms are clearly overt seizure events, and there are variable EEG patterns associated with this ictus. There remains a debate about the definitional boundaries of hypsarrhythmia, and about the defining characteristics of NCSE. There is evidence that hypsarrhythmia is an age-dependent EEG pattern that evolves, sometimes independently of clinical features. Frequently, hypsarrhythmia is associated with delay in or regression of neuro-developmental skills, and recent studies have reported that a longer lead time to diagnosis and effective treatment is associated with poorer long-term neuro-developmental outcomes. Recent consensus definitions and classifications of NCSE have suggested boundaries that permit inclusion of hypsarrhythmia as an EEG pattern of NCSE. In practice, adopting the idea that hypsarrhythmia is a form of NCSE might lead to earlier appropriate investigation of infants with subtle developmental delay or regression, hence avoiding treatment delays and potentially preserving developmental potential.

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