慢性乙醇摄入对胼胝体前列腺形态的影响。

M Martinez, F A Milton, S A de Oliveira, G S Reis, S Pereira, T M Segatelli, P F F Pinheiro, C C D Almeida, V H A Cagnon, W Mello, C R Padovani, F E Martinez
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引用次数: 0

摘要

本研究的目的是评估慢性酒精摄入对啮齿动物Calomys callosus前列腺腺上皮超微结构的可能毒性作用,以有助于了解酒精滥用对雄性生殖器官形态的影响。16只3个月大的成年动物分为两组。对照组饲喂固体饲粮和自来水,酒精组饲喂同样的固体饲粮和20%水稀释的乙醇P.A. (v/v)。治疗120天后,所有动物麻醉、称重并处死。在治疗结束时,对照组和酗酒动物的平均体重没有差异。酒精组前列腺上皮细胞出现严重萎缩和超微结构改变,如脂滴出现、核改变、线粒体嵴破裂和颗粒内质网池强烈扩张。结果表明,20%乙醇可引起前列腺上皮明显病变,可能干扰了腺体分泌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological alterations on the prostate of Calomys callosus submitted to chronic ethanol ingestion.

The objective of the present study was to assess the possible toxic effects of chronic alcohol ingestion on the ultrastructure of the glandular epithelium of the prostate of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the male reproductive apparatus. Sixteen adult animals aged three months were divided into two experimental groups. The control group received a solid diet and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 120 days of treatment, all animals were anesthetized, weighed and sacrificed. At the end of treatment, mean body weight did not differ between control and alcoholic animals. The prostate epithelial cells of the alcoholic group showed intense atrophy and ultrastructural alterations such as the presence of lipid droplets, altered nuclei, ruptured mitochondrial cristae, and intense dilatation of the cisterns of the granular endoplasmic reticulum. It was concluded that 20% ethanol provokes marked lesions on the epithelium of the prostate probably interfering on the glandular secretion.

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