肿瘤中的干细胞和神经发生。

Q4 Biochemistry, Genetics and Molecular Biology

Progress in Tumor Research Pub Date : 2007-01-01 DOI:10.1159/000100072

Judith A Varner

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引用次数: 7

摘要

骨髓源性和组织驻留干细胞通过促进新血管、肌肉和神经的形成来促进损伤组织的修复。这些相同的干细胞可能有助于肿瘤的生长和扩散。肿瘤表达多种生长因子，诱导血管生成和神经生成;这些因素也可能诱导组织驻留干细胞募集和分化。肿瘤还会招募循环的骨髓干细胞或祖细胞，这些细胞在促进肿瘤生长和扩散中发挥作用。由于肿瘤的神经支配促进癌性疼痛并有助于肿瘤的扩散，因此了解干细胞在肿瘤神经支配中的作用将有助于开发新的癌症治疗方法。

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Stem cells and neurogenesis in tumors.

Bone-marrow-derived and tissue-resident stem cells promote repair of injured tissues by contributing to new blood vessel, muscle and nerve formation. These same stem cells may contribute to tumor growth and spread. Tumors express numerous growth factors that induce both angiogenesis and neurogenesis; these factors may also induce tissue-resident stem cell recruitment and differentiation. Tumors also recruit circulating bone-marrow-derived stem or progenitor cells, which play roles in promoting tumor growth and spread. As innervation of tumors promote cancer pain and can contribute to tumor spread, an understanding of the roles of stem cells in tumor innervation will assist in the development of new cancer therapies.

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来源期刊

Progress in Tumor Research 医学-肿瘤学

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： The scientific book series ''Progress in Tumor Research'' aims to provide in depth information about important developments in cancer research. The individual volumes are authored and edited by experts to provide detailed coverage of topics selected as either representing controversial issues or belonging to areas where the speed of developments necessitates the kind of assistance offered by integrative, critical reviews.