{"title":"细胞系统生物学能拯救药物发现吗?","authors":"E C Butcher","doi":"10.1007/978-3-540-31339-7_8","DOIUrl":null,"url":null,"abstract":"<p><p>The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease, not target selection, qualify drug candidates for the clinic. We consider a biology-driven approach to drug discovery based on screening compounds by automated response profiling in complex human cell systems-based disease models. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.</p>","PeriodicalId":80277,"journal":{"name":"Ernst Schering Research Foundation workshop","volume":" 61","pages":"153-72"},"PeriodicalIF":0.0000,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"28","resultStr":"{\"title\":\"Can cell systems biology rescue drug discovery?\",\"authors\":\"E C Butcher\",\"doi\":\"10.1007/978-3-540-31339-7_8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease, not target selection, qualify drug candidates for the clinic. We consider a biology-driven approach to drug discovery based on screening compounds by automated response profiling in complex human cell systems-based disease models. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.</p>\",\"PeriodicalId\":80277,\"journal\":{\"name\":\"Ernst Schering Research Foundation workshop\",\"volume\":\" 61\",\"pages\":\"153-72\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ernst Schering Research Foundation workshop\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-540-31339-7_8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ernst Schering Research Foundation workshop","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-540-31339-7_8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease, not target selection, qualify drug candidates for the clinic. We consider a biology-driven approach to drug discovery based on screening compounds by automated response profiling in complex human cell systems-based disease models. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.
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