肺炎支原体的粘附蛋白。

IF 3.1 4区生物学 Q2 Immunology and Microbiology

Frontiers in Bioscience-Landmark Pub Date : 2007-01-01 DOI:10.2741/2093

Rama Chaudhry, Avanish Kumar Varshney, Pawan Malhotra

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引用次数: 39

摘要

支原体是独特的细胞壁缺陷，需要胆固醇，高度多形性细菌，具有非常小的基因组。肺炎支原体是一种重要的人类病原体，具有专门的尖端细胞器介导细胞粘附。这是一个复杂的多因子过程，需要一组支原体蛋白，如P1、P30、P116和HMW1-3。主要支原体粘附蛋白在异源表达系统中的表达为研究这些蛋白在致病性中的作用提供了机会，并有助于开发诊断试剂。在这篇综述中，我们重点介绍了各种细胞粘附蛋白在肺炎支原体中的作用。

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Adhesion proteins of Mycoplasma pneumoniae.

Mycoplasmas are unique cell wall deficient, cholesterol requiring, highly pleomorphic bacteria that possess very small genome. M. pneumoniae is an important human pathogen that possesses specialized tip organelle to mediate cytadherence. It is a complex multifactorial process requiring a group of mycoplasma proteins such as P1, P30, P116 and HMW1-3. Expression of major mycoplasma adhesin proteins in heterologous expression systems provides an opportunity to study the role(s) of these proteins in pathogenicity and helps to develop diagnostic reagents. In this review we highlight the role(s) of various cytadhesin proteins of M. pneumoniae.

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来源期刊

Frontiers in Bioscience-Landmark 生物-生化与分子生物学

CiteScore

3.40

自引率

3.20%

发文量

301

审稿时长

3 months

期刊介绍： FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.