直肠癌局部复发的执行结果

C. Billiet, P. Berard, F. Rivoalan, P. Neyra, C. Gouillat
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引用次数: 5

摘要

研究目的局部复发直肠癌(LRRC)的治疗仍然是一个困难且有争议的问题。本研究的目的是回顾性评估在需要时使用内脏切除,不切除骶骨,但包括术中放疗(IORT)的情况下,对可切除病变进行单姿态相关切除的结果。1989年至1999年间,32例患者接受了LRRC切除术。其中12人曾接受过腹部会阴切除术,22人接受过放疗。23例患者行盆腔切除术(共17例,腹直肌皮瓣18例)。25例患者接受IORT。结果术后早期死亡3例(9.3%),并发症11例(37%)。6例患者切除为R0, 21例为R1, 5例为R2。总体和无残疾的5年生存率分别为12%、12%和5%。总体和无残疾的中位生存期分别为22个月和12个月。结论LRRC的切除仍是一个手术挑战。它可以达到平均一年的无残疾生存,并希望有一些治愈。肿瘤结果的改善可能来自更准确的患者选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Résultats de l'exérèse des récidives locorégionales des cancers du rectum

Aims of the study

The treatment of locally recurrent rectal cancer (LRRC) remains a difficult and controversial issue. The aim of this study was to retrospectively assess the results of an univocal attitude associating resection of a priori resectable lesions using visceral excisions as required, without sacral excision, but including intra-operative radiotherapy (IORT).

Patients and methods

Between 1989 and 1999, 32 patients underwent resection for LRRC. Twelve had previously undergone abdomino-perineal excision and 22 had received radiotherapy. Twenty-three patients underwent pelvic exenteration (total in 17, with rectus myocutaneous flap in 18). Twenty-five patients underwent IORT.

Results

Three patients (9.3%) died in the early postoperative period and 11 experienced complications (37%). Resections were considered R0 in 6 patients, R1 in 21 patients and R2 in 5 patients. Five-year survival rates, overall and without disability, were respectively 12%, 12% and 5%. Median survivals, overall and without disability, were respectively 22 and 12 months.

Conclusion

Resection of LRRC remains a surgical challenge. It may achieve an average of one-year survival without disability, and hope for a few cures. Improvement of oncologic results might come from a more accurate patient selection.

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