J L Snoep, H V Westerhoff, J M Rohwer, J H S Hofmeyr
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Is there an optimal ribosome concentration for maximal protein production?
A core model is presented for protein production in Escherichia coli to address the question whether there is an optimal ribosomal concentration for non-ribosome protein production. Analysing the steady-state solution of the model over a range of mRNA concentrations, indicates that such an optimum ribosomal content exists, and that the optimum shifts to higher ribosomal contents at higher specific growth rates.
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