胆总管梗阻后应变能功能的重构。

Quang Dang, Hans Gregersen, Birgitte Duch, Ghassan S Kassab
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引用次数: 0

摘要

胆管梗阻是影响全世界数百万人的重要临床疾病。我们之前的研究表明,胆总管(CBD)在梗阻后经历了显著的生长和重塑。机械应力-应变关系预计会因生长和重塑而改变,以响应阻塞和压力过载。本研究的目的是表征假手术组和梗阻后3小时、12小时、2天、8天、32天(每组n=5) CBD的材料特性。采用冯氏指数应变能函数将正常和重塑管道的应力与应变联系起来。采用Marquardt-Levenberg和遗传算法确定了指数应变能函数的材料常数。两种方法得到的弹性常数无显著差异(p>0.254)。得到了各时间点稳定收敛的材料常数。在最初的12小时内剧烈阻塞后,决定周向应力相对于应变非线性变化率的材料常数显著增加。,在第2天下降,最后在剩余的30天中呈单调上升。最初刚度的急剧增加仅仅是由于弹性响应。慢性重塑过程导致最初的周向软化,随后CBD变硬。本研究对CBD梗阻患者及内窥镜医师和外科医生治疗该病具有重要的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Remodeling of strain energy function of common bile duct post obstruction.

Biliary duct obstruction is an important clinical condition that affects millions of people worldwide. We have previously shown that the common bile duct (CBD) undergoes significant growth and remodelling post obstruction. The mechanical stress-strain relation is expected to change due to growth and remodeling in response to obstruction and hence pressure-overload. The objective of the present study was to characterize the material properties of the CBD of the sham group and at 3 hours, 12 hours, 2 days, 8 days and 32 days (n=5 in each group) after obstruction. The Fung's exponential strain energy function was used to relate stress to strain of the normal and remodeled ducts. The Marquardt-Levenberg and genetic algorithm methods were used for the determination of material constants for the exponential strain energy function. The elastic constants obtained by the two methods did not differ (p>0.254). We obtained stable and convergent material constants at every time point. The material constant that dictates the nonlinear rate of change in the circumferential stress with respect to strain increased significantly after obstruction acutely in the first 12 hrs., decreased at 2 days and finally increased montonically during the remaining 30 days. The acute initial increase in stiffness was simply due to the elastic response. The chronic remodeling process results in an initial circumferential softening followed by stiffening of the CBD. This study has important clinical significance for patients with CBD obstruction and for endoscopists and surgeons who treat the condition.

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