饲粮蛋白质对妊娠大鼠氨基酸供应及苏氨酸代谢的影响。

Reproduction, nutrition, development Pub Date : 2006-05-01 Epub Date: 2006-05-30 DOI:10.1051/rnd:2006015
William D Rees, Susan M Hay, Christos Antipatis
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引用次数: 17

摘要

为了研究饮食中蛋白质含量对妊娠期间苏氨酸代谢的影响,研究人员给大鼠喂食含有18%或9%蛋白质的饮食,然后在妊娠的不同阶段杀死它们。饲粮中蛋白质含量为9%的动物血清苏氨酸浓度下降的速度明显快于饲粮中蛋白质含量为18%的动物。妊娠第4天,饲粮中蛋白质含量为18%的母鼠肝脏匀浆中苏氨酸氧化率较高。随着妊娠的进行,两组小鼠肝脏匀浆苏氨酸氧化率均有所下降。妊娠各阶段母猪肝脏苏氨酸脱氢酶活性不受饲料蛋白质含量的影响。在妊娠早期,饲喂高蛋白饲料的母鼠肝脏匀浆中丝氨酸-苏氨酸脱水酶活性短暂增加,而饲喂低蛋白饲料的母鼠肝脏匀浆中丝氨酸-苏氨酸脱水酶活性不变。在妊娠后期,肾脏中的丝氨酸-苏氨酸脱水酶活性有所增加,但这并不受母体饮食中蛋白质含量的影响。这些数据表明,游离苏氨酸浓度的变化不能通过氧化速率的变化来解释,并表明一些其他因素影响了妊娠期间这种氨基酸的异常代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of dietary protein on the amino acid supply and threonine metabolism in the pregnant rat.

To characterise the effects of dietary protein content on threonine metabolism during pregnancy, rats were fed diets containing 18% or 9% protein and then killed at different stages of gestation. Serum threonine concentrations fell significantly faster in the animals fed the diet containing 9% protein when compared to those fed the diet containing 18% protein. On day 4 of gestation the rate of threonine oxidation was higher in maternal liver homogenates prepared from the animals fed the diet containing 18% protein. The rate of threonine oxidation by liver homogenates fell as gestation proceeded in both diet groups. The activity of threonine dehydrogenase in the maternal liver was unaffected by dietary protein content at all stages of gestation. Serine-threonine dehydratase activity in homogenates of the maternal liver was transiently increased during the early stages of gestation in the animals fed high protein diets but was unchanged in the low protein groups. There was an increase in serine-threonine dehydratase activity in the kidney during the later stages of gestation but this was unaffected by the protein content of the maternal diet. These data show that the changes in free threonine concentrations cannot be accounted for through changes in the oxidation rate and suggest that some other factor influences the unusual metabolism of this amino acid during gestation.

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