{"title":"配体诱导的蛋白酶体雌激素受体α降解:新的参与者?","authors":"Mathilde Calligé, Hélène Richard-Foy","doi":"10.1621/nrs.04004","DOIUrl":null,"url":null,"abstract":"<p><p>In this perspective we consider new aspects of ligand-induced estrogen receptor alpha (ERalpha) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERalpha and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERalpha degradation and transcription activation. A model for ERalpha action integrating these new actors is proposed and the relation between hormone-induced ERalpha degradation and transcription-activation is discussed.</p>","PeriodicalId":87415,"journal":{"name":"Nuclear receptor signaling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1621/nrs.04004","citationCount":"41","resultStr":"{\"title\":\"Ligand-induced estrogen receptor alpha degradation by the proteasome: new actors?\",\"authors\":\"Mathilde Calligé, Hélène Richard-Foy\",\"doi\":\"10.1621/nrs.04004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this perspective we consider new aspects of ligand-induced estrogen receptor alpha (ERalpha) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERalpha and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERalpha degradation and transcription activation. A model for ERalpha action integrating these new actors is proposed and the relation between hormone-induced ERalpha degradation and transcription-activation is discussed.</p>\",\"PeriodicalId\":87415,\"journal\":{\"name\":\"Nuclear receptor signaling\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1621/nrs.04004\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear receptor signaling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1621/nrs.04004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2006/2/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear receptor signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1621/nrs.04004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2006/2/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Ligand-induced estrogen receptor alpha degradation by the proteasome: new actors?
In this perspective we consider new aspects of ligand-induced estrogen receptor alpha (ERalpha) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERalpha and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERalpha degradation and transcription activation. A model for ERalpha action integrating these new actors is proposed and the relation between hormone-induced ERalpha degradation and transcription-activation is discussed.
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