驱虫药奥芬达唑最大残留限量(MRL)对雌雄小鼠的遗传毒性、致畸和生化影响。

Reproduction, nutrition, development Pub Date : 2006-03-01 Epub Date: 2006-04-06 DOI:10.1051/rnd:2006007
Aida El-Makawy, Hasnaa A Radwan, Inas S Ghaly, A Abd El-Raouf
{"title":"驱虫药奥芬达唑最大残留限量(MRL)对雌雄小鼠的遗传毒性、致畸和生化影响。","authors":"Aida El-Makawy,&nbsp;Hasnaa A Radwan,&nbsp;Inas S Ghaly,&nbsp;A Abd El-Raouf","doi":"10.1051/rnd:2006007","DOIUrl":null,"url":null,"abstract":"<p><p>Oxfendazole, methyl-5 (6)-phenylsulfinyl-2-benzimidazole carbamate, is a member of the benzimidazole family of anthelmintics. Anthelmintic benzimidazoles are widely used in meat producing animals (cattle, sheep and pigs) for control of endoparasites. The extensive use of veterinary drugs in food-producing animals can cause the presence of small quantities of the drug residues in food. Maximum residue limit or \"MRL\" means the maximum concentration of residue resulting from the use of a veterinary medicinal product which may be legally permitted recognized as acceptable in food. The FAO/WHO Expert Committee on Food Additives (1999) evaluations of toxicological and residue data, reported that oxfendazole (MRL) has toxicological hazards on human health. The toxicity of oxfendazole (MRL) was tested in male and female mice and their fetuses. Chromosomal aberrations, teratological examination and biochemical analysis were the parameters used in this study. The results show that oxfendazole MRL induced a mutagenic effect in all tested cell types. Also, oxfendazole exhibit embryotoxicity including teratogenicity. The biochemical results show that oxfendazole induced a disturbance in the different biochemical contents of all tested tissues. So, we must increase the attention paid to the potential risk of oxfendazole residues in human beings and should stress the need for careful control to ensure adherence to the prescribed withdrawal time of this drug.</p>","PeriodicalId":21133,"journal":{"name":"Reproduction, nutrition, development","volume":"46 2","pages":"139-56"},"PeriodicalIF":0.0000,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1051/rnd:2006007","citationCount":"27","resultStr":"{\"title\":\"Genotoxical, teratological and biochemical effects of anthelmintic drug oxfendazole Maximum Residue Limit (MRL) in male and female mice.\",\"authors\":\"Aida El-Makawy,&nbsp;Hasnaa A Radwan,&nbsp;Inas S Ghaly,&nbsp;A Abd El-Raouf\",\"doi\":\"10.1051/rnd:2006007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oxfendazole, methyl-5 (6)-phenylsulfinyl-2-benzimidazole carbamate, is a member of the benzimidazole family of anthelmintics. Anthelmintic benzimidazoles are widely used in meat producing animals (cattle, sheep and pigs) for control of endoparasites. The extensive use of veterinary drugs in food-producing animals can cause the presence of small quantities of the drug residues in food. Maximum residue limit or \\\"MRL\\\" means the maximum concentration of residue resulting from the use of a veterinary medicinal product which may be legally permitted recognized as acceptable in food. The FAO/WHO Expert Committee on Food Additives (1999) evaluations of toxicological and residue data, reported that oxfendazole (MRL) has toxicological hazards on human health. The toxicity of oxfendazole (MRL) was tested in male and female mice and their fetuses. Chromosomal aberrations, teratological examination and biochemical analysis were the parameters used in this study. The results show that oxfendazole MRL induced a mutagenic effect in all tested cell types. Also, oxfendazole exhibit embryotoxicity including teratogenicity. The biochemical results show that oxfendazole induced a disturbance in the different biochemical contents of all tested tissues. So, we must increase the attention paid to the potential risk of oxfendazole residues in human beings and should stress the need for careful control to ensure adherence to the prescribed withdrawal time of this drug.</p>\",\"PeriodicalId\":21133,\"journal\":{\"name\":\"Reproduction, nutrition, development\",\"volume\":\"46 2\",\"pages\":\"139-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1051/rnd:2006007\",\"citationCount\":\"27\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproduction, nutrition, development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1051/rnd:2006007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2006/4/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproduction, nutrition, development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1051/rnd:2006007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2006/4/6 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 27

摘要

奥菲达唑,甲基-5(6)-苯基亚砜基-2-苯并咪唑氨基甲酸酯,是苯并咪唑类驱虫药的一员。驱虫药苯并咪唑广泛用于肉类生产动物(牛、羊和猪),以控制体内寄生虫。在食用动物中广泛使用兽药可导致食品中存在少量药物残留。最大残留限量或“MRL”是指使用兽药产品产生的最高残留浓度,该浓度可能被法律允许并被认为是食品中可接受的。粮农组织/世界卫生组织食品添加剂专家委员会(1999年)对毒理学和残留数据的评价报告说,奥芬达唑(MRL)对人类健康具有毒理学危害。研究了奥芬达唑(MRL)对雌雄小鼠及其胎儿的毒性作用。染色体畸变、畸形检查和生化分析是本研究的参数。结果表明,奥芬达唑MRL对所有被试细胞类型均有诱变作用。此外,奥芬达唑表现出胚胎毒性,包括致畸性。生化结果表明,奥芬达唑对各组组织的不同生化成分均有干扰作用。因此,我们必须增加对奥芬达唑残留在人体中的潜在风险的重视,并应强调需要仔细控制,以确保遵守规定的停药时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genotoxical, teratological and biochemical effects of anthelmintic drug oxfendazole Maximum Residue Limit (MRL) in male and female mice.

Oxfendazole, methyl-5 (6)-phenylsulfinyl-2-benzimidazole carbamate, is a member of the benzimidazole family of anthelmintics. Anthelmintic benzimidazoles are widely used in meat producing animals (cattle, sheep and pigs) for control of endoparasites. The extensive use of veterinary drugs in food-producing animals can cause the presence of small quantities of the drug residues in food. Maximum residue limit or "MRL" means the maximum concentration of residue resulting from the use of a veterinary medicinal product which may be legally permitted recognized as acceptable in food. The FAO/WHO Expert Committee on Food Additives (1999) evaluations of toxicological and residue data, reported that oxfendazole (MRL) has toxicological hazards on human health. The toxicity of oxfendazole (MRL) was tested in male and female mice and their fetuses. Chromosomal aberrations, teratological examination and biochemical analysis were the parameters used in this study. The results show that oxfendazole MRL induced a mutagenic effect in all tested cell types. Also, oxfendazole exhibit embryotoxicity including teratogenicity. The biochemical results show that oxfendazole induced a disturbance in the different biochemical contents of all tested tissues. So, we must increase the attention paid to the potential risk of oxfendazole residues in human beings and should stress the need for careful control to ensure adherence to the prescribed withdrawal time of this drug.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信