氢键如何塑造膜蛋白结构。

Advances in Protein Chemistry Pub Date : 2005-01-01 DOI:10.1016/S0065-3233(05)72006-4

Stephen H White

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引用次数: 36

摘要

除非肽键参与氢键，否则将肽键分配到膜双分子层的能量成本是令人望而却步的。然而，即使在这种情况下，使肽键脱水的自由能损失也很大，这只能通过有利的疏水相互作用来克服。因此，膜蛋白结构的形成是由氢键相互作用主导的，这是本综述的主题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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How hydrogen bonds shape membrane protein structure.

The energetic cost of partitioning peptide bonds into membrane bilayers is prohibitive unless the peptide bonds participate in hydrogen bonds. However, even then there is a significant free energy penalty for dehydrating the peptide bonds that can only be overcome by favorable hydrophobic interactions. Membrane protein structure formation is thus dominated by hydrogen bonding interactions, which is the subject of this review.

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Advances in Protein Chemistry

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