[无情绪压力的tako -tsubo样综合征1例报告]。

Andrea Rognoni, Valentina Conti, Marta Leverone, Paolo Marino
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引用次数: 0

摘要

tako-tsubo样综合征(也称为左心室心尖球囊)是一种罕见的心肌病,在日本女性人群中发病率高,由情绪压力引起。临床表现(典型胸痛)、心电图(T波阴性、前导联持续st段抬高)、超声心动图(一过性左室心尖功能障碍伴基底段运动亢进)提示急性前路心肌梗死;然而,所有的文献报道显示冠状动脉没有血管造影病变。我们报告一例77岁女性患者(无心血管危险因素),既往有两次阵发性心房颤动,因胸痛、心电图和超声心动图特征,提示急性前壁心肌梗死,之前没有任何情绪压力而到达急诊科。冠状动脉造影显示冠状动脉无动脉粥样硬化病变;左心室造影显示心尖前功能障碍。随访2个月后经胸超声心动图显示局部壁运动异常完全消退。病理生理决定因素似乎与儿茶酚胺(如肾上腺素和去甲肾上腺素)的释放有关,儿茶酚胺能够通过直接的细胞损伤产生短暂的缺血性心肌病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Tako-tsubo-like syndrome without emotional stress: a case report].

The tako-tsubo-like syndrome (also named left ventricular apical ballooning) is an unusual cardiomyopathy with a high incidence in the Japanese female population, following an emotional stress. The clinical features (typical chest pain), electrocardiographic (negative T wave and persistent ST-segment elevation in anterior leads), echocardiographic (transient left ventricular apical dysfunction with hyperkinesis of basal segments) are suggestive of an acute anterior myocardial infarction; nevertheless all reports in the literature show coronary arteries without angiographic lesions. We report the case of a 77-year-old female (without cardiovascular risk factors) with two prior episodes of paroxysmal atrial fibrillation, who arrived to the emergency department with chest pain, electrocardiographic and echocardiographic features, suggestive of an acute anterior myocardial infarction, not preceded by any emotional stress. Coronary angiography showed coronary arteries without atherosclerotic lesions; left ventriculography showed an anteroapical dysfunction. The follow-up performed with transthoracic echocardiography (2 months later) showed complete regression of regional wall motion abnormalities. The pathophysiological determinant seems to be related to the release of catecholamines (such as epinephrine and norepinephrine) able to create a transient board of ischemic cardiomyopathy through a direct cellular damage.

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