氯丙嗪治疗小儿躁动的疗效评价。

The Mental Health Clinician Pub Date : 2021-03-31 eCollection Date: 2021-03-01 DOI:10.9740/mhc.2021.03.040
Rajwoana Ahmed, Megan Maroney, Germin Fahim, Hoytin Lee Ghin, Andrew Scott Mathis
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引用次数: 2

摘要

氯丙嗪是第一代用于儿科患者行为问题的抗精神病药物。然而,其他疗法可能既改善了结果,又减少了副作用。在我们的机构里,氯丙嗪一直是治疗小儿躁动的标准药物。本研究的目的是评估氯丙嗪使用的适宜性(包括疗效、合适的剂量、药物相互作用和耐受性),以优化小儿躁动的治疗。方法:收集2019年1月至2019年6月服用氯丙嗪的每位患者的药物相互作用、患者行为、剂量和副作用等数据。数据分析采用描述性统计评估药物-药物相互作用(ddi)的发生率,无效的发生率,不适当的剂量和副作用。结果:共对70例患者和130次口服或肌注氯丙嗪进行了评估。在这些治疗中,49例(38%)导致DDI。18次(14%)用药对控制躁动症状无效。11例(8%)给药不当,46例(35%)给药产生可能由氯丙嗪引起的副作用。讨论:本研究的结果表明,由于氯丙嗪的药物相互作用、无效、剂量不当和副作用,患者护理有改善的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the use of chlorpromazine for agitation in pediatric patients.

Introduction: Chlorpromazine is a first-generation antipsychotic used for behavioral problems in pediatric patients. However, other therapies may demonstrate both improved outcomes and fewer side effects. Within our institution, chlorpromazine has been the standard medication used for treatment of pediatric agitation. The study objective was to evaluate the appropriateness of chlorpromazine use (including efficacy, appropriate dosing, drug interactions, and tolerability) to optimize the treatment of pediatric agitation.

Methods: Data regarding drug interactions, patient behavior, dosing, and side effects was collected for each patient administered chlorpromazine from January 2019 through June 2019. Data were analyzed using descriptive statistics assessing the incidence of drug-drug interactions (DDIs), incidences of inefficacy, inappropriate dosing, and side effects.

Results: A total of 70 patients and 130 administrations of oral or intramuscular chlorpromazine were evaluated. Of these administrations, 49 (38%) resulted in a DDI. Eighteen (14%) administrations were ineffective for managing symptoms of agitation. Eleven (8%) administrations were dosed inappropriately, and 46 (35%) administrations resulted in side effects possibly caused by chlorpromazine.

Discussion: Results from this study demonstrate opportunities for improvement in patient care due to instances of drug interactions, inefficacy, inappropriate dosing, and side effects with the use of chlorpromazine.

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