XPD和XPF基因多态性对高海拔地区非小细胞肺癌易感性的影响

IF 1.3 4区医学 Q4 GENETICS & HEREDITY

Public Health Genomics Pub Date : 2021-01-01 Epub Date: 2021-04-07 DOI:10.1159/000512641

Miao Li, Rong Chen, Baoyan Ji, Chunmei Fan, Guanying Wang, Chenli Yue, Guoquan Li

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引用次数: 0

摘要

背景:我们旨在探讨XPD和XPF变异与中国高海拔汉族人群非小细胞肺癌(NSCLC)风险的关系以及这些变异对顺铂化疗敏感性的影响。方法:采用Agena MassARRAY平台对506例非小细胞肺癌患者和510例健康对照进行XPD和XPF 8个单核苷酸多态性(snp)基因分型。采用logistic回归分析XPD和XPF基因多态性与NSCLC易感性及顺铂化疗疗效的相关性，计算比值比(ORs)和95%置信区间(CIs)。结果:XPD rs13181 (OR = 1.53, 95% CI: 1.04 ~ 2.24, p = 0.029)和rs1052555 (OR = 1.63, 95% CI: 1.05 ~ 2.53, p = 0.029)可能与肺腺癌发生风险增加有关，而XPD rs238406 (OR = 0.63, 95% CI: 0.43 ~ 0.94, p = 0.024)是肺鳞癌发生的保护因素。年龄、性别、BMI、吸烟和饮酒可能影响XPD和XPF多态性与NSCLC风险的相关性。更重要的是，XPD rs13181 (OR = 2.91, p = 0.015)、XPD rs1052555 (OR = 2.67, p = 0.022)和XPF rs231127 (OR = 4.15, p = 0.008)与接受顺铂化疗的NSCLC患者的治疗反应相关。结论:本研究发现XPD和XPF变异可能与中国高海拔地区汉族人群的NSCLC风险和顺铂化疗反应有关。

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Contribution of XPD and XPF Polymorphisms to Susceptibility of Non-Small Cell Lung Cancer in High-Altitude Areas.

Background: We aimed to explore the relation of XPD and XPF variants with non-small cell lung cancer (NSCLC) risk and the effect of these variants on the sensitivity to cisplatin-based chemotherapy among the Chinese Han population in high-altitude areas.

Methods: Eight single-nucleotide polymorphisms (SNPs) in XPD and XPF were genotyped by Agena MassARRAY platform among 506 NSCLC cases and 510 healthy controls. Correlation of XPD and XPF gene polymorphisms with NSCLC susceptibility and the response of cis-platin-based chemotherapy were analyzed with logistic regression by calculating odds ratios (ORs) and 95% confidence intervals (CIs).

Results: XPD rs13181 (OR = 1.53, 95% CI: 1.04-2.24, p = 0.029) and rs1052555 (OR = 1.63, 95% CI: 1.05-2.53, p = 0.029) possibly contributed to the increased risk of lung adenocarcinoma, while XPD rs238406 (OR = 0.63, 95% CI: 0.43-0.94, p = 0.024) was a protective factor for lung squamous cell carcinoma. Age, gender, BMI, smoking, and drinking might affect the correlation of XPD and XPF polymorphisms with NSCLC risk. More importantly, XPD rs13181 (OR = 2.91, p = 0.015), XPD rs1052555 (OR = 2.67, p = 0.022), and XPF rs231127 (OR = 4.15, p = 0.008) were associated with treatment response in NSCLC patients underwent cisplatin-based chemotherapy.

Conclusion: This study found that XPD and XPF variants might contribute to NSCLC risk and the response of cisplatin-based chemotherapy among the Chinese Han population in high-altitude areas.

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来源期刊

Public Health Genomics 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Public Health Genomics'' is the leading international journal focusing on the timely translation of genome-based knowledge and technologies into public health, health policies, and healthcare as a whole. This peer-reviewed journal is a bimonthly forum featuring original papers, reviews, short communications, and policy statements. It is supplemented by topic-specific issues providing a comprehensive, holistic and ''all-inclusive'' picture of the chosen subject. Multidisciplinary in scope, it combines theoretical and empirical work from a range of disciplines, notably public health, molecular and medical sciences, the humanities and social sciences. In so doing, it also takes into account rapid scientific advances from fields such as systems biology, microbiomics, epigenomics or information and communication technologies as well as the hight potential of ''big data'' for public health.