FKBP5基因变异与抑郁症易感性的关联:一项综合荟萃分析

IF 2.8 3区医学 Q2 PSYCHIATRY

Asia‐Pacific Psychiatry Pub Date : 2021-03-20 DOI:10.1111/appy.12464

Beifang Fan, Jianping Ma, Huimin Zhang, Yuhua Liao, Wanxin Wang, Sheng Zhang, Ciyong Lu, Lan Guo

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引用次数: 8

摘要

这项综合荟萃分析旨在结合不同研究的数据，并估计FKBP5多态性与抑郁症之间的关系。方法对观察性研究进行荟萃分析。在四个数据库中对2020年7月1日之前发表的文章进行了电子检索。结果共纳入16项独立研究的5125例抑郁症患者和8399例对照。结果显示，在共显性模型中，FKBP5 rs1360780与抑郁风险相关(CT vs. CC;Or = 1.10, 95% ci = 1.00-1.20, p = 0.04);rs4713916多态性在共显性模型中与抑郁相关(AG vs. GG;OR = 1.19, 95% CI = 1.05-1.34, P = 0.008)和隐性模型(AA vs. AG + GG;Or = 0.74, 95% ci = 0.56-0.99, p = 0.04);在共显性遗传模型中发现rs3800373与抑郁症之间存在显著关联(AC vs. AA;OR = 1.18, 95% CI = 1.05-1.34, P = .007)和优势模型(CC + AC vs. AA;Or = 1.15, 95% ci = 1.03-1.30, p = 0.02);在任何遗传模型中，FKBP5 rs9470080或rs9296158与抑郁症均无显著相关性(P > 0.05)。在我们的分析中未观察到发表偏倚。此外，敏感性分析显示Zobel的研究显著影响了rs4713916和rs3800373的异质性。结论在共显性模型中，FKBP5 rs1360780与抑郁风险增加相关。我们还发现rs4713916和rs3800373与抑郁有关，rs4713916在共显性模型和隐性模型中与抑郁呈正相关，rs3800373在共显性模型和显性模型中与抑郁风险升高相关。

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Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta-analysis

Background

This comprehensive meta-analysis aimed to combine data from different studies and to estimate the association between FKBP5 polymorphisms and depression.

Methods

We performed a meta-analysis of observational studies. An electronic search was conducted on four databases for articles published before July 1, 2020.

Results

A total of 5125 patients with depression and 8399 controls from 16 independent studies were included in the analysis. The results showed that FKBP5 rs1360780 was associated with the risk of depression in the codominant model (CT vs. CC; OR = 1.10, 95% CI = 1.00–1.20, P = .04); rs4713916 polymorphism was associated with depression in the codominant model (AG vs. GG; OR = 1.19, 95% CI = 1.05–1.34, P = .008) and recessive model (AA vs. AG + GG; OR = 0.74, 95% CI = 0.56–0.99, P = .04); a significant association between rs3800373 and depression was found in the codominant genetic model (AC vs. AA; OR = 1.18, 95% CI = 1.05–1.34, P = .007) and dominant model (CC + AC vs. AA; OR = 1.15, 95% CI = 1.03–1.30, P = .02); there was no significant association of FKBP5 rs9470080 or rs9296158 with depression in any genetic model (P > .05). No publication bias was observed in our analysis. Moreover, sensitivity analyses demonstrated the Zobel's study significantly affected the heterogeneity for rs4713916 and rs3800373.

Conclusions

FKBP5 rs1360780 was associated with an increased risk of depression in the codominant model. We also found that rs4713916 and rs3800373 were involved in depression, rs4713916 was positively associated with depression in the codominant model and recessive model, and rs3800373 was related to an elevated risk of depression in the codominant model and dominant model.

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来源期刊

Asia‐Pacific Psychiatry PSYCHIATRY-

CiteScore

7.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Asia-Pacific Psychiatry is an international psychiatric journal focused on the Asia and Pacific Rim region, and is the official journal of the Pacific Rim College of Psychiatrics. Asia-Pacific Psychiatry enables psychiatric and other mental health professionals in the region to share their research, education programs and clinical experience with a larger international readership. The journal offers a venue for high quality research for and from the region in the face of minimal international publication availability for authors concerned with the region. This includes findings highlighting the diversity in psychiatric behaviour, treatment and outcome related to social, ethnic, cultural and economic differences of the region. The journal publishes peer-reviewed articles and reviews, as well as clinically and educationally focused papers on regional best practices. Images, videos, a young psychiatrist''s corner, meeting reports, a journal club and contextual commentaries differentiate this journal from existing main stream psychiatry journals that are focused on other regions, or nationally focused within countries of Asia and the Pacific Rim.