青春期前肥胖症儿童体内脂肪连接素、TNFα和SHBG之间的关系。

IF 2.4 Q1 PEDIATRICS
Marta Ramon-Krauel, María Jesús Leal-Witt, Óscar Osorio-Conles, Montse Amat-Bou, Carles Lerin, David M Selva
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引用次数: 0

摘要

背景:与正常体重的人相比,成年肥胖症患者的性激素结合球蛋白(SHBG)水平较低。肥胖与肿瘤坏死因子α(TNFα)血浆水平升高和脂肪连素水平降低有关。此外,我们最近还阐明了 TNFα 和脂肪连通素调节肝脏 SHBG 生成的分子机制:方法:我们测定了体重正常儿童(n=15)和青春期前肥胖儿童(n=51)的多项形态计量和生化指标,并量化了血浆SHBG、TNFα受体1(TNFα-R1)和脂肪连接蛋白的水平:结果表明:与体重正常的对照组相比,青春期前肥胖症儿童的血浆SHBG水平降低(67 nmol/L vs 172 nmol/L)。重要的是,SHBG血浆水平与TNFα(负相关,ßstd= - 0.31)和脂肪连素(正相关,ßstd= 0.58)显著相关(P<0.05),这表明这两种细胞因子在决定青春期前儿童血浆SHBG水平方面起着重要作用:我们的研究结果表明,在青春期前肥胖症人群中,血浆脂肪连素水平对血浆SHBG水平的影响可能比TNFα更重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity.

Background: Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production.

Aim: The main objective of this study was to assess if the adult associations between TNFα, adiponectin, and SHBG are present in prepubertal children.

Methods: We determined several morphometric and biochemical parameters in normal-weight (n=15) and obese prepubertal (n=51) children, as well as quantified plasma SHBG, TNFα receptor 1 (TNFα-R1), and adiponectin levels.

Results: Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/L vs 172 nmol/L). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNFα (negatively, ßstd= - 0.31) and adiponectin (positively, ßstd= 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children.

Conclusions: Our results suggest that plasma adiponectin levels may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.

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